N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide

Base Information

• Chemical Name: N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide
• CAS No.: 127-73-1
• Molecular Formula: C13H14N4O3S
• Molecular Weight: 306.345
• European Community (EC) Number: 204-861-5
• UNII: S0D41HX8KG
• DSSTox Substance ID: DTXSID40155361
• Nikkaji Number: J184.360E
• Wikidata: Q83023261
• ChEMBL ID: CHEMBL1559815
• Mol file: 127-73-1.mol

Synonyms:N(4)-acetylsulfamerazine

Chemical Property of N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide

Chemical Property:

• Melting Point: 250-252°C
• Refractive Index: 1.609
• PSA: 109.43000
• Density: 1.429 g/cm³
• LogP: 2.77100
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly, Heated)
• Water Solubility.: 367.6mg/L(37 oC)
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 306.07866149
• Heavy Atom Count: 21
• Complexity: 455

Purity/Quality:

99% ^*data from raw suppliers

N-Acetylsulfamerazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=NC=C1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C
• Uses: The main metabolite of antibacterial drug Sulfamerazine.

Technology Process of N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide

There total 10 articles about N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sulfamerazina (127-79-7) + acetic anhydride (108-24-7) → N-[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide (127-73-1)

Guidance literature:

With pyridine;

DOI:10.1021/ja01631a079

Reference yield:

4-Methyl-pyrimidin-2-ylamin (108-52-1) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → N-[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide (127-73-1)

Guidance literature:

With pyridine;

DOI:10.1021/ja01262a034 DOI:10.1021/ja01856a046 DOI:10.1021/ja01865a027

Reference yield:

acetylacetaldehyde dimethyl acetal (5436-21-5) + N-(4-{[(aminoiminomethyl)amino]sulfonyl}phenyl)acetamide (19077-97-5) → N-[4-(4-Methyl-pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide (127-73-1)

Guidance literature:

With sodium ethanolate;

upstream raw materials:

4-Methyl-pyrimidin-2-ylamin

p-acetylaminobenzenesulfonyl chloride

2-chloro-4-methylpyrimidine

p-acetylaminobenzenesulfonamide

Downstream raw materials:

sulfamerazina