3-O-Methyl 6-Hydroxy-17β-estradiol

Base Information

Chemical Name:3-O-Methyl 6-Hydroxy-17β-estradiol
CAS No.:473882-84-7
Molecular Formula:C₂₄H₃₄O₄
Molecular Weight:386.532
Hs Code.:
Mol file:473882-84-7.mol

Synonyms:3-O-Methyl 6-Hydroxy-17β-estradiol;3-O-Methyl 6-Hydroxy-17β-estradiol 17-O-Tetrahydropyran

Suppliers and Price of 3-O-Methyl 6-Hydroxy-17β-estradiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-O-Methyl6-Hydroxy-17β-estradiol17-O-Tetrahydropyran
500mg
$ 1540.00

Total 3 raw suppliers

Chemical Property of 3-O-Methyl 6-Hydroxy-17β-estradiol

Chemical Property:

PSA：47.92000
LogP:4.95400
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3-O-Methyl6-Hydroxy-17β-estradiol17-O-Tetrahydropyran ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Labelled 17-Epiestriol intermediate.

Technology Process of 3-O-Methyl 6-Hydroxy-17β-estradiol

There total 6 articles about 3-O-Methyl 6-Hydroxy-17β-estradiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 473882-84-7
3-methoxy-17β-(2-tetrahydropyranyloxy)estra-1,3,5-trien-6α-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / picric acid / benzene

2: 1.) BuLi (2M in cyclohexane), potassium 1,1-dimethylpropoxide 2M in cyclohexane/THF, (i-Pr)2NH, 2.) B(OMe)3, 3.) 30percent H₂O₂ / 1.) hexane, -78 deg C, 3 h, 2.) THF, hexane, cyclohexane, 0 deg C, 3.) THF, hexane, cyclohexane, RT, 1 h

With tetrahydrofuran; n-butyllithium; Trimethyl borate; dihydrogen peroxide; potassium 2-methylbutan-2-olate; 2,4,6-Trinitrophenol; diisopropylamine; In benzene;
DOI:10.1055/s-1995-4136

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 473882-84-7
3-methoxy-17β-(2-tetrahydropyranyloxy)estra-1,3,5-trien-6β-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / picric acid / benzene

2: 1.) BuLi (2M in cyclohexane), potassium 1,1-dimethylpropoxide 2M in cyclohexane/THF, (i-Pr)2NH, 2.) B(OMe)3, 3.) 30percent H₂O₂ / 1.) hexane, -78 deg C, 3 h, 2.) THF, hexane, cyclohexane, 0 deg C, 3.) THF, hexane, cyclohexane, RT, 1 h

With tetrahydrofuran; n-butyllithium; Trimethyl borate; dihydrogen peroxide; potassium 2-methylbutan-2-olate; 2,4,6-Trinitrophenol; diisopropylamine; In benzene;
DOI:10.1055/s-1995-4136

Reference yield:

: 1035-77-4
3-O-methyl-17β-oestradiol

: 473882-84-7
3-methoxy-17β-(2-tetrahydropyranyloxy)estra-1,3,5-trien-6α-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / picric acid / benzene

2: 1.) BuLi (2M in cyclohexane), potassium 1,1-dimethylpropoxide 2M in cyclohexane/THF, (i-Pr)2NH, 2.) B(OMe)3, 3.) 30percent H₂O₂ / 1.) hexane, -78 deg C, 3 h, 2.) THF, hexane, cyclohexane, 0 deg C, 3.) THF, hexane, cyclohexane, RT, 1 h

With tetrahydrofuran; n-butyllithium; Trimethyl borate; dihydrogen peroxide; potassium 2-methylbutan-2-olate; 2,4,6-Trinitrophenol; diisopropylamine; In benzene;
DOI:10.1055/s-1995-4136