4-Iodo Suberoylanilide HydroxaMic Acid

Base Information

• Chemical Name: 4-Iodo Suberoylanilide HydroxaMic Acid
• CAS No.: 1219807-87-0
• Molecular Formula: C14H19IN2O3
• Molecular Weight: 390.221
• Mol file: 1219807-87-0.mol

Synonyms:4-Iodo Suberoylanilide HydroxaMic Acid;4-iodo-SAHA;N1-Hydroxy-N8-(4-iodophenyl)octanediaMide

Chemical Property of 4-Iodo Suberoylanilide HydroxaMic Acid

Chemical Property:

• PSA: 78.43000
• LogP: 3.53960
• Solubility.: insoluble in H2O; insoluble in EtOH; ≥1.67 mg/mL in DMSO

Purity/Quality:

97% ^*data from raw suppliers

4-Iodo Suberoylanilide Hydroxamic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A SAHA derivative with antiproliferative activity in several human cancer cell lines. A SAHA derivative with antiproliferative activity in several human cancer cell lines. Antitumor agent.

Technology Process of 4-Iodo Suberoylanilide HydroxaMic Acid

There total 1 articles about 4-Iodo Suberoylanilide HydroxaMic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

C15H20INO3 → N-hydroxy-N'-(4-iodophenyl)octanediamide (1219807-87-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In methanol; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.bioorg.2019.103452

Refernces

• 1、 Salmi-Smail, Chanaz,Fabre, Aurélie,Dequiedt, Franck,Restouin, Audrey,Castellano, Rémy,Garbit, Slaveia,Roche, Philippe,Morelli, Xavier,Brunel, Jean Michel,Collette, Yves. "Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity". experimental part. p. 3038 - 3047. Retrieved 2010/09/07.