Technology Process of 1-(TRIFLUOROMETHYL)CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
There total 1 articles about 1-(TRIFLUOROMETHYL)CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 15 h / 75 °C
2.1: hydroxylamine sulfate; sodium hydroxide / water; methanol / 80 °C
2.2: 80 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C
With
sodium hydride; hydroxylamine sulfate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2015.07.023
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 15 h / 75 °C
2.1: hydroxylamine sulfate; sodium hydroxide / water; methanol / 80 °C
2.2: 80 °C
3.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C
4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate / water; acetonitrile / 1 h / 90 °C
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium hydride; sodium carbonate; hydroxylamine sulfate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2015.07.023
