Technology Process of Cyclohepta[b]pyrrole, 2-(1-methylethyl)- (9CI)
There total 5 articles about Cyclohepta[b]pyrrole, 2-(1-methylethyl)- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(cyclohepta-2,4,6-trienyl)-3-methylbutan-2-one O-pentafluorobenzoyloxime;
With
triethylamine;
tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium(0);
In
N,N-dimethyl-formamide;
at 80 ℃;
for 1h;
With
manganese(IV) oxide;
In
dichloromethane;
for 2h;
Heating;
DOI:10.1246/cl.2002.606
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / CH2Cl2 / 0.25 h / 0 °C
2.1: molecular sieves 4 Angstroem; t-Bu3P; triethylamine / bis(dibenzylideneacetone)palladium(0) / dimethylformamide; toluene / 1 h / 80 °C
2.2: 62 percent / MnO2 / CH2Cl2 / 2 h / Heating
With
tri-tert-butyl phosphine; 4 A molecular sieve; triethylamine;
bis(dibenzylideneacetone)-palladium(0);
In
dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.77.785
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.83 h / -78 °C
1.2: 50 percent / tetrahydrofuran / 1.5 h / -78 - 20 °C
2.1: pyridine; hydroxylamine hydrochloride / ethanol / 12 h / 60 °C
3.1: triethylamine / CH2Cl2 / 0.25 h / 0 °C
4.1: molecular sieves 4 Angstroem; t-Bu3P; triethylamine / bis(dibenzylideneacetone)palladium(0) / dimethylformamide; toluene / 1 h / 80 °C
4.2: 62 percent / MnO2 / CH2Cl2 / 2 h / Heating
With
pyridine; tri-tert-butyl phosphine; 4 A molecular sieve; hydroxylamine hydrochloride; triethylamine; lithium diisopropyl amide;
bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1246/bcsj.77.785