4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid

Base Information

• Chemical Name: 4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid
• CAS No.: 885015-52-1
• Molecular Formula: C₁₇H₁₁F₃N₂O₃
• Molecular Weight: 348.281
• Mol file: 885015-52-1.mol

Synonyms:4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid

Chemical Property of 4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid

There total 4 articles about 4-(1-(4-(Trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

methyl (1H-pyrazol-3-yl)benzoate + 1-bromo-4-(trifluoromethoxy)benzene (407-14-7) → 4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid (885015-52-1)

Guidance literature:

With copper(l) iodide; 8-quinolinol; caesium carbonate; In water; N,N-dimethyl-formamide; at 120 ℃; for 20h;

Reference yield: 16.0%

1-bromo-4-(trifluoromethoxy)benzene (407-14-7) + methyl 4-(1H-pyrazol-3-yl)benzoate (179057-10-4) → 4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid (885015-52-1)

Guidance literature:

With copper(l) iodide; 8-quinolinol; water; caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 20h;

Reference yield:

methyl 4-acetylbenzoate (3609-53-8) → 4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoic acid (885015-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 20 h / 105 °C

2: hydrazine hydrate / ethanol / 30 h / 50 - 60 °C

3: copper(l) iodide; 8-quinolinol; caesium carbonate / water; N,N-dimethyl-formamide / 20 h / 120 °C

With copper(l) iodide; 8-quinolinol; caesium carbonate; hydrazine hydrate; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-acetylbenzoate

1-bromo-4-(trifluoromethoxy)benzene

(E)-methyl 4-(3-(dimethylamino)acryloyl)benzoate

methyl 4-(1H-pyrazol-3-yl)benzoate

Downstream raw materials:

4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)benzoyl azide

N-[[(2-isopropylphenyl)amino]thioxomethyl]-N'-((4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)phenyl))urea