6-p-tolylsulfonyl-3-Pyridazinol

Base Information

• Chemical Name: 6-p-tolylsulfonyl-3-Pyridazinol
• CAS No.: 99985-09-8
• Molecular Formula: C₁₁H₁₀N₂O₃S
• Molecular Weight: 250.278
• Mol file: 99985-09-8.mol

Synonyms:6-p-tolylsulfonyl-3-Pyridazinol

Chemical Property of 6-p-tolylsulfonyl-3-Pyridazinol

Chemical Property:

• Melting Point: 185-186 °C
• PKA: 9.54±0.40(Predicted)
• PSA: 88.27000
• Density: 1.39±0.1 g/cm3(Predicted)
• LogP: 1.99190

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-p-tolylsulfonyl-3-Pyridazinol

There total 5 articles about 6-p-tolylsulfonyl-3-Pyridazinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-6-(toluene-4-sulfonyl)-pyridazine → 6-(toluene-4-sulfonyl)-2H-pyridazin-3-one (99985-09-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/jm034065z

Reference yield:

para-thiocresol (106-45-6) → 6-(toluene-4-sulfonyl)-2H-pyridazin-3-one (99985-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Na; MeOH / toluene

2: MCPBA / CH₂Cl₂

3: HCl / dioxane

With hydrogenchloride; methanol; sodium; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1021/jm034065z

Reference yield:

3-methoxy-6-p-tolylsulfanyl-pyridazine → 6-(toluene-4-sulfonyl)-2H-pyridazin-3-one (99985-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: MCPBA / CH₂Cl₂

2: HCl / dioxane

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jm034065z

upstream raw materials:

3,6-dichlorpyridazine

para-thiocresol

Downstream raw materials:

3-chloro-6-(toluene-4-sulfonyl)-pyridazine

Refernces