cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine

Base Information

• Chemical Name: cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine
• CAS No.: 1187055-62-4
• Molecular Formula: C₁₁H₁₉F₃N₂O₂
• Molecular Weight: 268.279
• Mol file: 1187055-62-4.mol

Synonyms:cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine;cis-3-(Boc-aMino)-5-(trif...;tert-butyl N-[cis-5-(trifluoromethyl)piperidin-3-yl]carbamate

Chemical Property of cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

cis-3-(Boc-amino)-5-(trifluormethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine

There total 10 articles about cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidine-1-carboxylate (1620240-17-6) → tert-butyl [(3S,5R)-5-(trifluoromethyl)piperidin-3-yl]carbamate (1620012-51-2,1187055-62-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 2h; under 1292.9 Torr;

Reference yield:

tert-butyl N-[5-(trifluoromethyl)-3-pyridyl]carbamate (1187055-61-3) → tert-butyl [5-(trifluoromethyl)piperidin-3-yl]carbamate (1187055-62-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; 5% rhodium-on-charcoal; In acetic acid; at 70 ℃; for 48h; under 10343.2 Torr; Inert atmosphere;

Reference yield:

tert-butyl N-[5-(trifluoromethyl)-3-pyridyl]carbamate (1187055-61-3) → cis-3-(Boc-amino)-5-(trifluoromethyl)piperidine (1187055-62-4)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; 5% rhodium-on-charcoal; at 70 ℃; for 48h; under 10343.2 Torr;

upstream raw materials:

tert-butyl N-[5-(trifluoromethyl)-3-pyridyl]carbamate

di-tert-butyl dicarbonate

5-(trifluoro-methyl)pyridin-3-amine

tert-butyl N-tert-butoxycarbonyl-N-[5-(trifluoromethyl)-3-pyridyl]carbamate

Downstream raw materials:

tert-butyl [(3S,5R)-5-(trifluoromethyl)piperidin-3-yl]carbamate

benzyl {2-[({4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]-7-morpholin-4-ylquinolin-3-yl}carbamate

benzyl [2-[({4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]-7-(4-methylpiperazin-1-yl)quinolin-3-yl]carbamate

benzyl {7-bromo-2-[({4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)carbonyl]quinolin-3-yl}carbamate

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