Technology Process of 1-aMino-4-broMo-2-naphthoic acid
There total 8 articles about 1-aMino-4-broMo-2-naphthoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
at 0 - 15 ℃;
for 1h;
- Guidance literature:
-
With
alkali metal hydroxide;
In
tetrahydrofuran; water;
at 50 - 90 ℃;
for 22h;
Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00095
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 39 h / 120 °C
2.1: potassium carbonate; potassium permanganate / water; tert-butyl alcohol / 17.5 h / 20 °C
3.1: hydrogenchloride / 42 h / 0 - 90 °C
4.1: hydrogen / palladium on activated charcoal / tetrahydrofuran; methanol / 14 h / 760.05 Torr
5.1: bromine / 1,4-dioxane; tetrachloromethane / 2 h / 0 °C
6.1: sodium hydroxide / water; tetrahydrofuran / 22 h / 50 - 90 °C
6.2: 2 h
With
hydrogenchloride; potassium permanganate; hydrogen; bromine; potassium carbonate; sodium hydroxide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; toluene; tert-butyl alcohol;
