4-Methanesulfonyl-2-Methoxyaniline

Base Information

• Chemical Name: 4-Methanesulfonyl-2-Methoxyaniline
• CAS No.: 41608-73-5
• Molecular Formula: C8H11NO3S
• Molecular Weight: 201.246
• Hs Code.: 2922299090
• Mol file: 41608-73-5.mol

Synonyms:4-Methanesulfonyl-2-Methoxyaniline

Chemical Property of 4-Methanesulfonyl-2-Methoxyaniline

Chemical Property:

• PSA: 77.77000
• LogP: 2.34290
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%+, ^*data from raw suppliers

2-Methoxy-4-(methylsulfonyl)aniline 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methanesulfonyl-2-Methoxyaniline

There total 5 articles about 4-Methanesulfonyl-2-Methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2-methoxy-4-(methylsulfonyl)aniline (41608-73-5)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 75 ℃; for 3h;

Reference yield: 92.0%

2-methoxy-4-(methylsulfonyl)-1-nitrobenzene → 2-methoxy-4-(methylsulfonyl)aniline (41608-73-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 18h; under 760.051 Torr;

Reference yield:

tert-butyl (2-methoxy-4-(methylsulfonyl)phenyl)carbamate → 2-methoxy-4-(methylsulfonyl)aniline (41608-73-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 25 ℃; for 1h;

upstream raw materials:

2-methoxy-4-(methylsulfanyl)-1-nitrobenzene

4-fluoro-2-methoxy-1-nitrobenzene

Downstream raw materials:

N₂-(2-methoxy-4-(methylsulfonyl)phenyl)-N₄-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine

Refernces

• 1、 -. "CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF". Paragraph 0263; 0266. . Retrieved 2018/03/25.
• 2、 -. "NEW SUBSTITUTED CYANOINDOLINE DERIVATIVES AS NIK INHIBITORS". Page/Page column 238; 244. . Retrieved 2017/08/20.