2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI)

Base Information

Chemical Name:2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI)
CAS No.:354988-40-2
Molecular Formula:C₉H₁₃NO₂
Molecular Weight:167.208
Hs Code.:
Mol file:354988-40-2.mol

Synonyms:2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI)

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Technology Process of 2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI)

There total 6 articles about 2H-1,3-Oxazin-2-one,6-ethynyltetrahydro-4-(1-methylethyl)-,(4R,6S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 354988-33-3
(3R,5R)-5-[N-(tert-butoxycarbonyl)amino]-6-methyl-1-trimethylsilylhept-1-yn-3-ol

: 354988-40-2
(3R,6R)-6-ethynyl-4-isopropyl-1,3-oxazaperhydroin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jo015683v

Reference yield: 45.0%

: 354988-32-2
(3S,5R)-5-[N-(tert-butoxycarbonyl)amino]-6-methyl-1-trimethylsilylhept-1-yn-3-ol

: 354988-40-2
(4R,6S)-6-ethynyl-4-isopropyl-1,3-oxazaperhydroin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 1.5h;
DOI:10.1021/jo015683v

Reference yield:

: 172695-23-7
(R)-3-<(tert-butoxycarbonyl)amino>-4-methylpentanenitrile

: 354988-40-2
(3R,6R)-6-ethynyl-4-isopropyl-1,3-oxazaperhydroin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / DIBAL-H / CHCl₃; toluene / 1.5 h / -78 - -30 °C

2: 38 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3: 72 percent / NaH / CH₂Cl₂; tetrahydrofuran / 1.5 h / 0 - 20 °C

With n-butyllithium; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; chloroform; toluene;
DOI:10.1021/jo015683v