Lorcaserin hydrochloride

Base Information

Chemical Name:Lorcaserin hydrochloride
CAS No.:1431697-94-7
Molecular Formula:C11H14ClN.HCl
Molecular Weight:232.153
Hs Code.:
Mol file:1431697-94-7.mol

Synonyms:8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride (1:1)

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Chemical Property of Lorcaserin hydrochloride

Chemical Property:

PSA：12.03000
LogP:3.72000
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Lorcaserin hydrochloride is a hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug. It has a role as a serotonergic agonist and an appetite depressant. It contains a lorcaserin(1+).Lorcaserin (hydrochloride) is an analytical reference material categorized as an anorectic.It also decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in the rat.Lorcaserin is regulated as a Schedule IV compound in the United States. (±)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride Hemihydrate is used to prepare and study structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Technology Process of Lorcaserin hydrochloride

There total 21 articles about Lorcaserin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 4-(8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-3-nitrobenzene sulfonic acid

: 1431697-94-7,1006037-59-7
(±)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Guidance literature:: 4-(8-chloro-1-methyl-1,2,4,5-tetrahydro-3H-benzo[d]azepin-3-yl)-3-nitrobenzene sulfonic acid; With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With hydrogenchloride; In 1,4-dioxane;