methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate

Base Information

Chemical Name:methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate
CAS No.:132691-44-2
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate;methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate

Suppliers and Price of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate

There total 5 articles about methyl 3-(4-((tert-butoxycarbonylamino)methyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103565-40-8
4-(Aminomethyl)benzenepropanoic acid methyl ester hydrochloride

: 24424-99-5
di-tert-butyl dicarbonate

: 132691-44-2
methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 3-[4-(tert-butoxycarbonylamino-methyl)-phenyl]-acrylic acid methyl ester

: 132691-44-2
methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;
DOI:10.1039/c3md00214d

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 132691-44-2
methyl 4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]benzenepropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / 2 h / 20 °C / Inert atmosphere

2: triethylamine; bis(triphenylphosphine)palladium(II) dichloride; lithium chloride / N,N-dimethyl-formamide / 3 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: hydrogen; palladium 10% on activated carbon / methanol / 3 h / 20 °C

With bis(triphenylphosphine)palladium(II) dichloride; palladium 10% on activated carbon; hydrogen; triethylamine; lithium chloride; In methanol; N,N-dimethyl-formamide; isopropyl alcohol; 2: |Heck Reaction;
DOI:10.1039/c3md00214d