RG120

Base Information

Chemical Name:RG120
CAS No.:1448347-49-6
Molecular Formula:C28H22ClF3N6O3
Molecular Weight:582.969
Hs Code.:
Mol file:1448347-49-6.mol

Synonyms:RG120;Ivosidenib;(S)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide;(2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide;Glycinamide, 1-(4-cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)-, (2S)-

Suppliers and Price of RG120

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
AG-120(Ivosidenib) >98%
250 mg
$ 700.00

DC Chemicals
AG-120(Ivosidenib) >98%
1 g
$ 1200.00

DC Chemicals
AG-120(Ivosidenib) >98%
100 mg
$ 400.00

Crysdot
Ivosidenib 98+%
25mg
$ 321.00

Crysdot
Ivosidenib 98+%
100mg
$ 1026.00

Crysdot
Ivosidenib 98+%
50mg
$ 611.00

ChemScene
Ivosidenib 99.78%
100mg
$ 624.00

ChemScene
Ivosidenib 99.78%
50mg
$ 384.00

ChemScene
Ivosidenib 99.78%
5mg
$ 80.00

ChemScene
Ivosidenib 99.78%
10mg
$ 147.00

Total 38 raw suppliers

Chemical Property of RG120

Chemical Property:

Boiling Point:854.3±65.0 °C(Predicted)
PKA:11.58±0.40(Predicted)
PSA：119.29000
Density:1.51±0.1 g/cm3(Predicted)
LogP:4.78048
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

AG-120(Ivosidenib) >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) that specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of 2-hydroxyglutarate. AG-120 may induce cellular differentiation as well as inhibit proliferation in IDH1-expressing tumor cells.
Uses Ivosidenib is a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers.

Technology Process of RG120

There total 30 articles about RG120 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 33252-30-1
2-chloro-4-pyridinenitrile

: (S)-N-((S)-1-(2-chlorophenyl)-2- ((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

: 1448347-49-6,2070009-31-1
(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In acetic acid methyl ester; toluene; Solvent; Reflux; Inert atmosphere;

Reference yield: 22.0%

: 33252-30-1
2-chloro-4-pyridinenitrile

: (S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

: 1448347-49-6,2070009-31-1
(2S)-N-{(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 3h;
DOI:10.1021/acsmedchemlett.7b00421