N-(2-Methoxyphenyl)isonicotinamide

Base Information

• Chemical Name: N-(2-Methoxyphenyl)isonicotinamide
• CAS No.: 70301-28-9
• Molecular Formula: C13H12N2O2
• Molecular Weight: 228.25
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID301273005
• Nikkaji Number: J2.779.238C
• Mol file: 70301-28-9.mol

Synonyms:N-(2-Methoxyphenyl)isonicotinamide;70301-28-9;N-(2-methoxyphenyl)pyridine-4-carboxamide;N-(2-Methoxyphenyl)-4-pyridinecarboxamide;Oprea1_370679;Oprea1_726875;F1170-0071;IFLab1_005065;SCHEMBL8714717;DTXSID301273005;HMS1426G05;AMY10568;AKOS001023821;4-[(2-Methoxyanilino)carbonyl]pyridine;FT-0735831;L10163;Z27797394

Chemical Property of N-(2-Methoxyphenyl)isonicotinamide

Chemical Property:

• Boiling Point: 305℃
• PKA: 11.22±0.70(Predicted)
• Flash Point: 138℃
• PSA: 51.22000
• Density: 1.230
• LogP: 2.41550
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.089877630
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-METHOXYPHENYL)-4-PYRIDINECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1NC(=O)C2=CC=NC=C2

Technology Process of N-(2-Methoxyphenyl)isonicotinamide

There total 3 articles about N-(2-Methoxyphenyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine-4-carboxylic acid (55-22-1) + 2-methoxy-phenylamine (90-04-0) → 4-[(2-methoxyanilino)carbonyl]pyridine (70301-28-9)

Guidance literature:

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 4-[(2-methoxyanilino)carbonyl]pyridine (70301-28-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: triethylamine / benzene / 10 h / Heating

With thionyl chloride; triethylamine; In benzene; 1: Substitution / 2: Acylation;

DOI:10.1007/BF02464277

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) + 2-methoxy-phenylamine (90-04-0) → 4-[(2-methoxyanilino)carbonyl]pyridine (70301-28-9)

Guidance literature:

With triethylamine; In benzene; for 10h; Heating;

DOI:10.1007/BF02464277

upstream raw materials:

4-(chlorocarbonyl)pyridine

2-methoxy-phenylamine

pyridine-4-carboxylic acid