1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl

Base Information

• Chemical Name: 1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl
• CAS No.: 1216658-90-0
• Molecular Formula: C10H13ClFN
• Molecular Weight: 201.671
• Mol file: 1216658-90-0.mol

Synonyms:1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl;1-(4-fluorophenyl)cyclobutanaMine hydrochloride;1-(4-Fluorophenyl)-cyclobutanamine HCl

Chemical Property of 1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl

Chemical Property:

• PSA: 26.02000
• LogP: 3.66590

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Fluorophenyl)cyclobutan-1-aminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl

There total 2 articles about 1-(4-Fluorophenyl)cyclobutan-1-aMine, HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.1%

1-(4-fluorophenyl)cyclobutane-1-carboxamide → 1-(4-fluorophenyl)cyclobutane-1-amine hydrochloride (1216658-90-0)

Guidance literature:

1-(4-fluorophenyl)cyclobutane-1-carboxamide; With sodium hypochlorite; sodium hydroxide; In water; butan-1-ol; at 20 ℃; for 17h;

With hydrogenchloride; In 1,4-dioxane; ethyl acetate;

Reference yield: 23.75%

1-(4-Fluorophenyl)cyclobutanecarboxylic Acid → 1-(4-fluorophenyl)cyclobutane-1-amine hydrochloride (1216658-90-0)

Guidance literature:

1-(4-Fluorophenyl)cyclobutanecarboxylic Acid; With diphenylphosphoranyl azide; triethylamine; In tert-butyl alcohol; at 20 - 80 ℃; for 13h;

With hydrogenchloride; In water; at 80 ℃; for 12h;

Reference yield: 69.7%

ethyl 2-chloropyrimidine-5-carboxylate (89793-12-4) + 1-(4-fluorophenyl)cyclobutane-1-amine hydrochloride (1216658-90-0) → ethyl 2-((1-(4-fluorophenyl)cyclobutyl)amino)pyrimidine-5-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 110 ℃; for 17h;

Downstream raw materials:

N-[1-(4-fluorophenyl)cyclobutyl]-2-(2-oxo-3-phenylpiperidin-1-yl)acetamide

Refernces

• 1、 -. "Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same". Paragraph 0410; 0417-0419. . Retrieved 2017/07/18.