1-(2-Deoxy-α-D-erythro-pentofuranosyl)-2(1H)-pyridinone

Base Information

• Chemical Name: 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-2(1H)-pyridinone
• CAS No.: 22882-18-4
• Molecular Formula: C10H13NO4
• Molecular Weight: 211.21452
• Mol file: 22882-18-4.mol

Synonyms:1-(2'-Desoxy-α-D-ribofuranosyl)-pyridon-(2);3-(2-Deoxy-α-D-ribofuranosyl)-2-pyridone;1-(2-Desoxy-α-D-ribofuranosyl)-pyridon-(2);1-((2S,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyridin-2-one;1-(2-Desoxy-α-D-ribofuranosyl)pyridon-(2);

Chemical Property of 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-2(1H)-pyridinone

Chemical Property:

• Melting Point: 102 °C (acetone)
• PSA: 71.69000
• LogP: -0.51100

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-2(1H)-pyridinone

There total 5 articles about 1-(2-Deoxy-α-D-erythro-pentofuranosyl)-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2(1H)-pyridone (24616-99-7) → 1-(2'-Desoxy-α-D-ribofuranosyl)-pyridon-(2) (22882-18-4)

Guidance literature:

With ammonia; In methanol; for 24h; Ambient temperature;

Reference yield:

2-Pyridone (142-08-5,1199357-22-6) → 1-(2'-Desoxy-α-D-ribofuranosyl)-pyridon-(2) (22882-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) KOH / 1) CH₃CN, 5 min, room temp.; 2) 10 min, room temp.

2: 45 percent / p-CH₃C₆H₄SO₃H / acetonitrile / 4 h / 65 °C

3: 85 percent / NH₃ / methanol / 24 h / Ambient temperature

With potassium hydroxide; ammonia; toluene-4-sulfonic acid; In methanol; acetonitrile;

Reference yield:

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride (4330-21-6) → 1-(2'-Desoxy-α-D-ribofuranosyl)-pyridon-(2) (22882-18-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) KOH / 1) CH₃CN, 5 min, room temp.; 2) 10 min, room temp.

2: 45 percent / p-CH₃C₆H₄SO₃H / acetonitrile / 4 h / 65 °C

3: 85 percent / NH₃ / methanol / 24 h / Ambient temperature

With potassium hydroxide; ammonia; toluene-4-sulfonic acid; In methanol; acetonitrile;

upstream raw materials:

1-<2'-deoxy-3',5'-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl>-2(1H)-pyridone

2-Pyridone

2-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyloxy>pyridine

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride