6-Bromo-4-fluoroisoindoline

Base Information

Chemical Name:6-Bromo-4-fluoroisoindoline
CAS No.:689214-92-4
Molecular Formula:C₈H₇BrFN
Molecular Weight:216.053
Hs Code.:
European Community (EC) Number:855-904-5
DSSTox Substance ID:DTXSID40595288
Wikidata:Q82490273
Mol file:689214-92-4.mol

Synonyms:6-bromo-4-fluoroisoindoline;689214-92-4;6-bromo-4-fluoro-2,3-dihydro-1H-isoindole;SCHEMBL3875504;DTXSID40595288;AKOS016845296;SB38332;BS-17376;CS-0312372;D82655;J-518395

Suppliers and Price of 6-Bromo-4-fluoroisoindoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
6-Bromo-4-fluoro-2,3-dihydro-1H-isoindole 96%
250mg
$ 249.00

Crysdot
6-Bromo-4-fluoroisoindoline 95+%
1g
$ 982.00

Chemenu
6-Bromo-4-fluoroisoindoline 95%
1g
$ 926.00

American Custom Chemicals Corporation
6-BROMO-4-FLUOROISOINDOLINE 95.00%
5MG
$ 504.78

Ambeed
6-Bromo-4-fluoroisoindoline 95+%
250mg
$ 361.00

Ambeed
6-Bromo-4-fluoroisoindoline 95+%
100mg
$ 181.00

Ambeed
6-Bromo-4-fluoroisoindoline 95+%
1g
$ 871.00

Alichem
6-Bromo-4-fluoroisoindoline
25g
$ 6150.60

Alichem
6-Bromo-4-fluoroisoindoline
5g
$ 2294.08

Total 6 raw suppliers

Chemical Property of 6-Bromo-4-fluoroisoindoline

Chemical Property:

PSA：12.03000
LogP:2.52020
Storage Temp.:2-8°C(protect from light)
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:214.97459
Heavy Atom Count:11
Complexity:153

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-4-fluoro-2,3-dihydro-1H-isoindole 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(CN1)C(=CC(=C2)Br)F

Technology Process of 6-Bromo-4-fluoroisoindoline

There total 4 articles about 6-Bromo-4-fluoroisoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: tert-butyl 5-bromo-7-fluoro-1-oxo-2,3-dihydro-1H-isoindole-2-carboxylate

: 689214-92-4
6-bromo-4-fluoro-2,3-dihydro-1H-isoindole

Guidance literature:: With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 70 ℃; for 3h; Inert atmosphere;

Reference yield:

: 957346-37-1
5-bromo-7-fluoro-2,3-dihydro-1H-isoindol-1-one

: 689214-92-4
6-bromo-4-fluoro-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 2 h / 20 - 30 °C

2: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran;

Reference yield:

: 1935921-64-4
methyl 4-bromo-2-(bromomethyl)-6-fluorobenzoate

: 689214-92-4
6-bromo-4-fluoro-2,3-dihydro-1H-isoindole

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 0.67 h / 40 °C

2: dmap / tetrahydrofuran / 2 h / 20 - 30 °C

3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 3 h / 70 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; ammonia; In tetrahydrofuran; methanol;