3-(Methylsulphonyl)benzyl bromide 97%

Base Information

• Chemical Name: 3-(Methylsulphonyl)benzyl bromide 97%
• CAS No.: 82657-76-9
• Molecular Formula: C8H9BrO2S
• Molecular Weight: 249.128
• Hs Code.: 2904909090
• Mol file: 82657-76-9.mol

Synonyms:3-(Methylsulphonyl)benzyl bromide 97%;1-(Bromomethyl)-3-(methylsulphonyl)benzene;3-(Methyl sulphonyl) benzyl broMide;1-(BroMoMethyl)-3-(Methylsulfonyl)benzene;1-(Bromomethyl)-3-(methylsulphonyl)benzene, 3-(Bromomethyl)phenyl methyl sulphone;Benzene, 1-(broMoMethyl)-3-(Methylsulfonyl)-;3-(Methylsulphonyl)benzylbromide97%;3-Methylsulfonylbenzyl bromide

Chemical Property of 3-(Methylsulphonyl)benzyl bromide 97%

Chemical Property:

• Boiling Point: 390.0±34.0 °C(Predicted)
• PSA: 42.52000
• Density: 1.550±0.06 g/cm3(Predicted)
• LogP: 3.06580
• Storage Temp.: 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

3-(Methylsulfonyl)benzyl bromide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Methylsulphonyl)benzyl bromide 97%

There total 4 articles about 3-(Methylsulphonyl)benzyl bromide 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 3-methylphenyl sulfone (10355-06-3) → 1-(bromomethyl)-3-(methylsulfonyl)benzene (82657-76-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; at 20 - 25 ℃; for 5h; Reagent/catalyst; Solvent;

Reference yield: 75.0%

(3-(methylsulfonyl)phenyl)methanol (220798-39-0) → 1-(bromomethyl)-3-(methylsulfonyl)benzene (82657-76-9)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.jmedchem.5b01982

Reference yield:

2-(3-(methylsulfonyl)phenyl)acetic acid (1877-64-1) → 1-(bromomethyl)-3-(methylsulfonyl)benzene (82657-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With N-Bromosuccinimide; lithium aluminium tetrahydride; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/acs.jmedchem.5b01982

upstream raw materials:

methyl 3-methylphenyl sulfone

2-(3-(methylsulfonyl)phenyl)acetic acid

(3-(methylsulfonyl)phenyl)methanol

meta-bromotoluene

Downstream raw materials:

[6-bromo-7-(3-methanesulphonylbenzyloxy)quinazolin-4-yl](isopropyl)amine

(E/Z)-N'-[2-cyano-5-(3-methanesulphonylbenzyloxy)-4-bromophenyl]-N,N-dimethylformamidine

methyl (S)-2-amino-3-(3-(methylsulfonyl)phenyl)propanoate

Refernces

• 1、 Wang, Shuang-Yan,Larsen, Younes,Navarrete, Cristina Vara,Jensen, Anders A.,Nielsen, Birgitte,Al-Musaed, Ali,Frydenvang, Karla,Kastrup, Jette Sandholm,Pickering, Darryl S.,Clausen, Rasmus Pr?torius. "Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues". . p. 2244 - 2254. Retrieved 2016/03/25.