2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)

Base Information

Chemical Name:2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)
CAS No.:199280-09-6
Molecular Formula:C₁₀H₉NO₄
Molecular Weight:207.186
Hs Code.:
Mol file:199280-09-6.mol

Synonyms:2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)

Suppliers and Price of 2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)

Chemical Property:

Melting Point:201 - 202 °C
PSA：85.69000
LogP:2.08840

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI)

There total 5 articles about 2-Benzofurancarboxylicacid,5-amino-7-hydroxy-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 199280-08-5
methyl 7-hydroxy-5-nitro-1-benzofuran-2-carboxylate

: 199280-09-6
5-Amino-7-hydroxy-benzofuran-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium/alumina; In tetrahydrofuran; methanol; for 4h; under 3102.9 Torr; Ambient temperature;
DOI:10.1021/jo971880b

Reference yield:

: 25672-29-1
7-methoxy-5-nitro-benzofuran-2-carboxylic acid

: 199280-09-6
5-Amino-7-hydroxy-benzofuran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / AcCl / 18 h / Heating

2: 97 percent / H₂ / Pd/Al₂O₃ / tetrahydrofuran; methanol / 4 h / 3102.9 Torr / Ambient temperature

With hydrogen; acetyl chloride; palladium/alumina; In tetrahydrofuran; methanol;
DOI:10.1021/jo971880b

Reference yield:

: 25672-28-0
Ethyl 7-methoxy-5-nitrobenzofuran-2-carboxylate

: 199280-09-6
5-Amino-7-hydroxy-benzofuran-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / DBU / ethanol / 4 h / Heating

2: 88 percent / Py*HCl / 18 h / 170 °C

3: 98 percent / AcCl / 18 h / Heating

4: 97 percent / H₂ / Pd/Al₂O₃ / tetrahydrofuran; methanol / 4 h / 3102.9 Torr / Ambient temperature

With hydrogen; pyridine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; palladium/alumina; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jo971880b