2-CHLOROL-4-PYRIDINE ACETIC ACID

Base Information

• Chemical Name: 2-CHLOROL-4-PYRIDINE ACETIC ACID
• CAS No.: 887580-55-4
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• Mol file: 887580-55-4.mol

Synonyms:2-CHLOROL-4-PYRIDINE ACETIC ACID;(2-CHLORO-PYRIDIN-4-YL)-ACETIC ACID;2-Chloro-4-pyridineacetic acid;2-Chloropyridine-4-acetic acid;2-Chloropyridine-4-acetic acid 97%;2-(2-chloropyridin-4-yl)acetic acid

Chemical Property of 2-CHLOROL-4-PYRIDINE ACETIC ACID

Chemical Property:

• Vapor Pressure: 3.74E-05mmHg at 25°C
• Melting Point: 140-145°C
• Boiling Point: 338.8°C at 760 mmHg
• PKA: 3.66±0.10(Predicted)
• Flash Point: 158.7°C
• PSA: 50.19000
• Density: 1.405g/cm³
• LogP: 1.36210
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-4-pyridineaceticacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROL-4-PYRIDINE ACETIC ACID

There total 3 articles about 2-CHLOROL-4-PYRIDINE ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.1%

ethyl 2-(2-chloropyridin-4-yl)acetate (937236-73-2) → 2-(2-chloropyridin-4-yl)acetic acid (887580-55-4)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 0 - 20 ℃; for 16h;

Reference yield: 57.0%

diethyl 2-(2-chloro-4-pyridinyl)malonate (896107-40-7) → 2-(2-chloropyridin-4-yl)acetic acid (887580-55-4)

Guidance literature:

With hydrogenchloride; water; for 18h; Reflux;

Reference yield:

2-chloro-4-picoline (3678-62-4) → 2-(2-chloropyridin-4-yl)acetic acid (887580-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydride / 0 - 20 °C

2: hydrogenchloride; water / 18 h / Reflux

With hydrogenchloride; water; potassium hydride;

upstream raw materials:

diethyl 2-(2-chloro-4-pyridinyl)malonate

ethyl 2-(2-chloropyridin-4-yl)acetate

2-chloro-4-picoline

Downstream raw materials:

1-(4-methylpiperazin-1-yl)-2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)ethanone

2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetic acid

methyl 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetate

2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide