((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester

Base Information

Chemical Name:((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester
CAS No.:149709-58-0
Molecular Formula:C20H23NO3
Molecular Weight:325.408
Hs Code.:
DSSTox Substance ID:DTXSID901149616
Mol file:149709-58-0.mol

Synonyms:149709-58-0;((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester;Tert-butyl N-[(2R)-1-oxo-3-(4-phenylphenyl)propan-2-yl]carbamate;tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate;[(1R)-2-(Biphenyl-4-yl)-1-formylethyl]carbamic acid tert-butyl ester;SCHEMBL9929938;OWIZSBUSCSIZSA-GOSISDBHSA-N;DTXSID901149616;BCP14994;ZFA70958;AM85596;AC-28986;CS-0009328;D72473;(R)-alpha-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal;(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate;tert-butyl(R)-(1-([1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate;1,1-Dimethylethyl N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-formylethyl]carbamate

Suppliers and Price of ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-?Butyl(R)?-?(1-?([1,?1''-Biphenyl]?-?4-?yl)?-?3-?oxopropan-?2-?yl)?carbamate
1g
$ 550.00

Total 27 raw suppliers

Chemical Property of ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester

Chemical Property:

Boiling Point:475.1±45.0 °C(Predicted)
PKA:11.17±0.46(Predicted)
PSA：55.40000
Density:1.097±0.06 g/cm3(Predicted)
LogP:4.37920
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:325.16779360
Heavy Atom Count:24
Complexity:402

Purity/Quality:

99.5% ^*data from raw suppliers

tert-?Butyl(R)?-?(1-?([1,?1''-Biphenyl]?-?4-?yl)?-?3-?oxopropan-?2-?yl)?carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=C(C=C1)C2=CC=CC=C2)C=O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H](CC1=CC=C(C=C1)C2=CC=CC=C2)C=O
Uses tert-?Butyl (R)?-?(1-?([1,?1''-Biphenyl]?-?4-?yl)?-?3-?oxopropan-?2-?yl)?carbamate is an impurity of LCZ696 (L270005), a novel dual-acting inhibitor of angiotensin II receptor and neprilysin, which can be used for blood pressure reduction.

Technology Process of ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester

There total 22 articles about ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 162972-36-3
(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-N-methoxy-N-metyl<1,1'-biphenyl>-4-propanamide

: 149709-58-0
(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 0.333333h;
DOI:10.1021/jm00010a014

Reference yield: 96.6%

: 1426129-50-1
N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester

: 304-91-6
o-iodosobenzoic acid

: 149709-58-0
(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In 1,2-dimethoxyethane; at 75 - 85 ℃; for 1h; Temperature; Solvent; Industrial scale;

Reference yield: 85.0%

: 1426129-50-1
N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester

: 149709-58-0
(R)-α-<<(1,1-dimethylethoxy)carbonyl>amino><1,1'-biphenyl>-4-propanal

Guidance literature:: With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; In dichloromethane; water; at 0 - 20 ℃; Solvent;