2,6-DibroMo-4-iodopyridine

Base Information

• Chemical Name: 2,6-DibroMo-4-iodopyridine
• CAS No.: 1160184-14-4
• Molecular Formula: C5H2Br2IN
• Molecular Weight: 362.79
• Mol file: 1160184-14-4.mol

Synonyms:2,6-DibroMo-4-iodopyridine

Chemical Property of 2,6-DibroMo-4-iodopyridine

Chemical Property:

• Melting Point: 180.7-181.6 °C (decomp)
• Boiling Point: 343.1±42.0 °C(Predicted)
• PKA: -5.04±0.10(Predicted)
• PSA: 12.89000
• Density: 2.646±0.06 g/cm3(Predicted)
• LogP: 3.21120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Dibromo-4-iodopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DibroMo-4-iodopyridine

There total 3 articles about 2,6-DibroMo-4-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-4-iodopyridine (1160184-14-4)

Guidance literature:

2,6-Dibromopyridine; With C₁₀H₂₀N^(1-)*Cl^(1-)*Mg⁽²⁺⁾*ClLi; In tetrahydrofuran; at -30 ℃; for 0.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; chemoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200801277

Reference yield: 85.0%

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-3-iodopyridine (1032582-80-1) + 2,6-dibromo-4-iodopyridine (1160184-14-4)

Guidance literature:

2,6-Dibromopyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; ZnCl₂-N,N,N’,N’-tetramethylethylenediamine; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101993

Reference yield: 71.0%

2,6-Dibromopyridine (626-05-1) → 2,6-dibromo-3-iodopyridine (1032582-80-1) + 2,6-dibromo-4-iodopyridine (1160184-14-4) + 2,6-dibromo-3,4-diiodopyridine (1353056-35-5) + 2,6-dibromo-3,5-diiodopyridine (1353056-36-6)

Guidance literature:

2,6-Dibromopyridine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Cd⁽²⁺⁾*2Cl^(1-)*(CH₃)2NCH₂CH₂N(CH₃)2=[CdCl₂((CH₃)2NCH₂CH₂N(CH₃)2)]; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

With iodine; In tetrahydrofuran; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101993

upstream raw materials:

2,6-Dibromopyridine

Downstream raw materials:

2,6-dibromo-4-phenylpyridine

Refernces

• 1、 -. "TYK-2 INHIBITOR". Paragraph 0376-0378. . Retrieved 2022/01/05.
• 2、 Rohbogner, Christoph J.,Wunderlich, Stefan H.,Clososki, Giuliano C.,Knochel, Paul. "New mixed Li/Mg and Li/Mg/Zn amides for the chemoselectlve metallation of arenes and heteroarenes". experimental part. p. 1781 - 1795. Retrieved 2009/09/05.