methyl 3-[(2-hydroxyethyl)sulfanyl]-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate

Base Information

Chemical Name:methyl 3-[(2-hydroxyethyl)sulfanyl]-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate
CAS No.:117068-49-2
Molecular Formula:C11H16N2O5S
Molecular Weight:288.32014
Hs Code.:
Mol file:117068-49-2.mol

Synonyms:(R,S)-Methyl 3-[(2-hydroxyethyl)thio]-3-thymin-1-yl-propanoate;Aids001076;Aids-001076;Thioacyclo-thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-[(2-hydroxyethyl)sulfanyl]-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate

Chemical Property:

PSA：126.95000
Density:1.344g/cm³
LogP:0.04450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 3-[(2-hydroxyethyl)sulfanyl]-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate

There total 2 articles about methyl 3-[(2-hydroxyethyl)sulfanyl]-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 117068-48-1
methyl (E)-3-thymin-1-ylpropenoate

: 60-24-2
2-hydroxyethanethiol

: 117068-49-2
(R,S)-methyl 3-[(2-hydroxyethyl)thio]-3-thymin-1-yl-propanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; Ambient temperature; overnight;
DOI:10.1021/jm00121a015

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 117068-49-2
(R,S)-methyl 3-[(2-hydroxyethyl)thio]-3-thymin-1-yl-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / DBU / acetonitrile / 93 h / Ambient temperature

2: 83 percent / DBU / tetrahydrofuran / Ambient temperature; overnight

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm00121a015