(S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE

Base Information

• Chemical Name: (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE
• CAS No.: 96145-91-4
• Molecular Formula: C₇H₁₂N₂O
• Molecular Weight: 140.185
• Hs Code.: 2933990090
• Mol file: 96145-91-4.mol

Synonyms:(S)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE;(S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE;(R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE;(R)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE;(8aS)-hexahydro-Pyrrolo[1,2-a]pyrazin-1(2H)-one

Chemical Property of (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE

Chemical Property:

• Melting Point: 68-70 °C
• Boiling Point: 318.4±35.0 °C (760 mmHg)
• PSA: 32.34000
• Density: 1.17±0.1 g/cm3(20 °C , 760mmHg)
• LogP: -0.15270

Purity/Quality:

(R)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE

There total 10 articles about (S)-HEXAHYDRO-PYRROLO[1,2-A]PYRAZIN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(S)-1-(2-Amino-ethyl)-pyrrolidine-2-carboxylic acid (917886-64-7) → L-5-Oxo-1,4-diazabicyclo<4.3.0>nonane (96145-91-4)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 6h;

Reference yield: 42.0%

(S)-1-(2-{[(S)-1-(2-{[(S)-1-(2-Amino-ethyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-pyrrolidine-2-carboxylic acid methyl ester → L-5-Oxo-1,4-diazabicyclo<4.3.0>nonane (96145-91-4) + (6S,15S,24S)-1,4,10,13,19,22-hexaazatetracyclo[22.3.0.06,10.015,19]heptacosane-5,14,23-trione (350028-13-6)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 720h;

DOI:10.1016/S0957-4166(01)00068-4

Reference yield: 23.0%

(S)-1-(2-{[(S)-1-(2-{[(S)-1-(2-Amino-ethyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-pyrrolidine-2-carbonyl]-amino}-ethyl)-pyrrolidine-2-carboxylic acid isopropyl ester → L-5-Oxo-1,4-diazabicyclo<4.3.0>nonane (96145-91-4) + (6S,15S)-1,4,10,13-tetraazatricyclo[13.3.0.06,10]octadecane-5,14-dione + (6S,15S,24S)-1,4,10,13,19,22-hexaazatetracyclo[22.3.0.06,10.015,19]heptacosane-5,14,23-trione (350028-13-6)

Guidance literature:

In methanol; Petroleum ether; at 50 ℃; for 168h; under 7500600 Torr;

DOI:10.1016/S0957-4166(01)00068-4

upstream raw materials:

ethyleneimine

ethyl (2S)-pyrrolidine-2-carboxylate

(S)-1-(2-Amino-ethyl)-pyrrolidine-2-carboxylic acid

(S)-1-(2-tert-butoxycarbonylaminoethyl)pyrrolidine-2-carboxylic acid tert-butyl ester

Downstream raw materials:

(S)-octahydropyrrolo[1,2-a]pyrazine

L-10-<β-N-(1,4-Diazabicyclo<4.3.o>nonanyl)propionyl>-2-chlorophenothiazine

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