Riluzole hydrochloride

Base Information

• Chemical Name: Riluzole hydrochloride
• CAS No.: 850608-87-6
• Molecular Formula: C8H6ClF3N2OS
• Molecular Weight: 270.66
• Mol file: 850608-87-6.mol

Synonyms:2-AMINO-6-TRIFLUOROMETHOXYBENZOTHIAZOLE HYDROCHLORIDE;RILUZOLE HCL;RILUZOLE HYDROCHLORIDE

Chemical Property of Riluzole hydrochloride

Chemical Property:

• PSA: 76.38000
• LogP: 4.16030

Purity/Quality:

≥98% by HPLC ^*data from raw suppliers

Riluzole hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Formulations containing riluzole have been explored as therapeutics for slowing disease progression of amyotrophic lateral sclerosis.
• Uses: Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals at an ED50 value of 4 mg/kg. Riluzole has been explored as a therapeutic for slowing disease progression of amyotrophic lateral sclerosis. Riluzole is a glutamate release inhibitor. It also induces caspase-dependent apoptosis and suppress cell proliferation in human heptocellular carcinoma. Riluzole is a neuroprotective and a anticancer agent.