Voxtalisib

Base Information

Chemical Name:Voxtalisib
CAS No.:934493-76-2
Deprecated CAS:1070896-79-5,1123889-87-1,1380852-52-7
Molecular Formula:C₁₃H₁₄N₆O
Molecular Weight:270.294
Hs Code.:29337900
UNII:CVL1685GPH
ChEMBL ID:CHEMBL3545366
DSSTox Substance ID:DTXSID701025755
Metabolomics Workbench ID:153393
NCI Thesaurus Code:C71704
Nikkaji Number:J3.527.559B
Pharos Ligand ID:53ASKM7396RU
Wikidata:Q27215232
Wikipedia:Voxtalisib
Mol file:934493-76-2.mol

Synonyms:SAR245409;voxtalisib;XL765

Suppliers and Price of Voxtalisib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one 97%
250mg
$ 7110.00

DC Chemicals
Voxtalisib(XL765,SAR245409) >98%
1 g
$ 1500.00

DC Chemicals
Voxtalisib(XL765,SAR245409) >98%
250 mg
$ 800.00

DC Chemicals
Voxtalisib(XL765,SAR245409) >98%
100 mg
$ 450.00

Crysdot
SAR245409 98+%
25mg
$ 450.00

Crysdot
SAR245409 98+%
50mg
$ 789.00

ChemScene
Voxtalisib 99.46%
100mg
$ 828.00

ChemScene
Voxtalisib 99.46%
50mg
$ 456.00

ChemScene
Voxtalisib 99.46%
10mg
$ 144.00

ChemScene
Voxtalisib 99.46%
25mg
$ 288.00

Total 14 raw suppliers

Chemical Property of Voxtalisib

Chemical Property:

Boiling Point:605.0±65.0 °C(Predicted)
PKA:12.54±0.10(Predicted)
PSA：103.21000
Density:1.397±0.06 g/cm3(Predicted)
LogP:1.02220
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:270.12290909
Heavy Atom Count:20
Complexity:425

Purity/Quality:

99%, ^*data from raw suppliers

2-Amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C2=NC(=NC(=C2C=C(C1=O)C3=CC=NN3)C)N
Recent ClinicalTrials:Open Label Treatment Extension Study With SAR245408 or SAR245409 as a Monotherapy or as a Combination Regimen
Recent EU Clinical Trials:Phase II Randomized Double Blind Placebo controlled Trial of Combination of Pimasertib with SAR245409 or of Pimasertib with SAR245409 Placebo in Subjects with Previously Treated Unresectable Low Grade Ovarian Cancer

Technology Process of Voxtalisib

There total 24 articles about Voxtalisib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1209500-07-1
C₁₄H₁₅N₅O₃S

: 934493-76-2,1123889-87-1
voxtalisib

Guidance literature:: With ammonia; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 934493-81-9
8-ethyl-4-methyl-2-(methylthio)-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one

: 934493-76-2
voxtalisib

Guidance literature:: 8-ethyl-4-methyl-2-(methylthio)-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7(8H)-one; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 4h;

With ammonia; In 1,4-dioxane; at 20 ℃;