7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole

Base Information

• Chemical Name: 7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole
• CAS No.: 1234847-45-0
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.213
• Hs Code.: 2934999090
• Mol file: 1234847-45-0.mol

Synonyms:7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole;Methyl 2-methyl-1,3-benzoxazole-7-carboxylate;ethyl 2-methylbenzo[d]oxazole-7-carboxylate

Chemical Property of 7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole

Chemical Property:

• Boiling Point: 301.7±15.0 °C(Predicted)
• PKA: -0.45±0.30(Predicted)
• PSA: 52.33000
• Density: 1.205±0.06 g/cm3(Predicted)
• LogP: 1.92280

Purity/Quality:

99% ^*data from raw suppliers

Methyl 2-methyl-1,3-benzoxazole-7-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole

There total 3 articles about 7-(Methoxycarbonyl)-2-methyl-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-aminosalicylic acid (570-23-0) + Triethyl orthoacetate (78-39-7) → ethyl 2-methylbenzoxazole-7-carboxylate (1234847-45-0)

Guidance literature:

With toluene-4-sulfonic acid; at 100 ℃; for 18h;

Reference yield: 24.0%

2-hydroxy-3-nitro-benzoic acid methyl ester (22621-41-6) + N,N-diethylaniline (91-66-7) → ethyl 3-amino-2-hydroxybenzoate (172092-29-4) + ethyl 2-methylbenzoxazole-7-carboxylate (1234847-45-0)

Guidance literature:

at 210 - 215 ℃; for 6h;

DOI:10.3987/COM-04-S(P)11

Reference yield: 21.0%

2-Hydroxy-3-nitrobenzoesaeureethylester (90564-38-8) + N,N-diethylaniline (91-66-7) → ethyl 3-amino-2-hydroxybenzoate (172092-29-4) + ethyl 2-methylbenzoxazole-7-carboxylate (1234847-45-0)

Guidance literature:

With N,N-diethylaniline; at 210 - 215 ℃; for 7h;

DOI:10.3987/COM-04-S(P)11

upstream raw materials:

2-hydroxy-3-nitro-benzoic acid methyl ester

N,N-diethylaniline

2-Hydroxy-3-nitrobenzoesaeureethylester

3-aminosalicylic acid

Refernces

• 1、 -. "GPR120 RECEPTOR AGONISTS AND USES THEREOF". Page/Page column 119. . Retrieved 2010/08/04.