(R)-paliperidone

Base Information

Chemical Name:(R)-paliperidone
CAS No.:130049-85-3
Molecular Formula:C23H27FN4O3
Molecular Weight:426.491
Hs Code.:
UNII:29F930S8Z1
DSSTox Substance ID:DTXSID60861376
Wikidata:Q27157247
ChEMBL ID:CHEMBL2361980
Mol file:130049-85-3.mol

Synonyms:(R)-paliperidone;130049-85-3;(R)-9-Hydroxy Risperidone;(+)-9-Hydroxyrisperidone;Paliperidone, (R)-;CHEBI:83806;29F930S8Z1;(9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;DTXCID2028985;9-hydroxy risperidone;(9R)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one;4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-, (9R)-;CAS-144598-75-4;DTXSID7049059;9R-Paliperidone;NCGC00183874-01;Paliperidone (Invega);SCHEMBL67205;CHEMBL2361980;UNII-29F930S8Z1;DTXSID60861376;PMXMIIMHBWHSKN-LJQANCHMSA-N;Tox21_113609;Tox21_113609_1;AM84407;CCG-213028;NCGC00186014-02;NCGC00389611-01;PD069838;AB01562960_01;A808242;A937348;Q27157247;(9~{R})-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;(9R)-3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-9-oxidanyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;(9R)-3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;(9R)-3-{2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;(9R)-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one;K4I

Suppliers and Price of (R)-paliperidone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-9-HydroxyRisperidone
10mg
$ 2230.00

Medical Isotopes, Inc.
(R)-9-HydroxyRisperidone
10 mg
$ 3250.00

Biosynth Carbosynth
(+)-9-Hydroxyrisperidone
5 mg
$ 1689.20

Biosynth Carbosynth
(+)-9-Hydroxyrisperidone
2 mg
$ 790.00

Biosynth Carbosynth
(+)-9-Hydroxyrisperidone
1 mg
$ 450.00

Biosynth Carbosynth
(+)-9-Hydroxyrisperidone
10 mg
$ 3071.30

American Custom Chemicals Corporation
(R)-PALIPERIDONE 95.00%
10MG
$ 3176.25

Total 9 raw suppliers

Chemical Property of (R)-paliperidone

Chemical Property:

PSA：84.39000
LogP:3.01920
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:426.20671890
Heavy Atom Count:31
Complexity:764

Purity/Quality:

97% ^*data from raw suppliers

(R)-9-HydroxyRisperidone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
Isomeric SMILES:CC1=C(C(=O)N2CCC[C@H](C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
Uses The R-enantiomer metabolite of Risperidone (R525000), a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

Technology Process of (R)-paliperidone

There total 19 articles about (R)-paliperidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₁₁H₁₅ClN₂O₂

: 84163-77-9
6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole

: 130049-85-3,147663-01-2
(+)-Paliperidone

Guidance literature:: With sodium hydroxide; In ethanol; at 75 ℃; for 5h; Reagent/catalyst;

Reference yield: 65.0%

: 1606138-67-3
C₂₁H₂₇ClN₂O₅

: 84163-13-3
6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride

: 130049-85-3,147663-01-2
(+)-Paliperidone

Guidance literature:: With tetra-(n-butyl)ammonium iodide; diisopropylamine; In methanol; at 45 ℃; for 48h;
DOI:10.2174/1570178611666140219004433