Base Information
- Chemical Name:(R)-non-8-en-2-ol
- CAS No.:211695-57-7
- Molecular Formula:C9H18O
- Molecular Weight:142.241
- Hs Code.:
- Mol file:211695-57-7.mol
Synonyms:(R)-non-8-en-2-ol
Synonyms:(R)-non-8-en-2-ol
97% *data from raw suppliers
The study presents the first total synthesis of greensporone C, a cytotoxic 14-membered resorcylic acid lactone with potential biological activities such as cytotoxicity against certain cancer cell lines. The synthesis involved a 16-step linear sequence with a 3.3% overall yield. Key chemicals used in the study include Mitsunobu reagents for esterification to construct the macrocycle and establish the (E)-olefin geometry, benzoic acid derivatives and (R)-non-8-en-2-ol as key fragments for the synthesis, and various protecting groups and reagents such as ethoxymethyl (EOM), t-butyldimethylsilyl chloride (TBSCl), and iodobenzene diacetate for protecting and modifying functional groups. The purpose of these chemicals was to construct the complex structure of greensporone C, confirm its absolute stereochemistry, and potentially unlock its biological activities for further study and application.
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