4-BroMo-2-(phenylMethoxy)phenol

Base Information

• Chemical Name: 4-BroMo-2-(phenylMethoxy)phenol
• CAS No.: 153240-85-8
• Molecular Formula: C₁₃H₁₁BrO₂
• Molecular Weight: 279.133
• Mol file: 153240-85-8.mol

Synonyms:2-Benzyloxy-4-broMophenol;4-BroMo-2-(phenylMethoxy)phenol

Chemical Property of 4-BroMo-2-(phenylMethoxy)phenol

Chemical Property:

• Boiling Point: 373.7±27.0 °C(Predicted)
• PKA: 8.94±0.43(Predicted)
• PSA: 29.46000
• Density: 1.478±0.06 g/cm3(Predicted)
• LogP: 3.73370
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Benzyloxy-4-bromophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Benzyloxy-4-bromophenol is an intermediate in the preparation of dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.

Technology Process of 4-BroMo-2-(phenylMethoxy)phenol

There total 7 articles about 4-BroMo-2-(phenylMethoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

O-benzylcatechol (6272-38-4) → 2-(benzyloxy)-4-bromophenol (153240-85-8)

Guidance literature:

With bromine; acetic acid; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00189

Reference yield:

C15H15BrO3 → 2-(benzyloxy)-4-bromophenol (153240-85-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → 2-(benzyloxy)-4-bromophenol (153240-85-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 3 h / Reflux

2: bromine; acetic acid / 1 h / 0 °C

With bromine; potassium carbonate; acetic acid; In acetone;

DOI:10.1016/j.bmc.2011.01.043

upstream raw materials:

O-benzylcatechol

benzyl bromide

benzene-1,2-diol

benzyl chloride

Refernces

• 1、 -. "Fused tricyclic compound and application in medicines". Paragraph 0407-0412. . Retrieved 2020/06/17.
• 2、 Li, Yue,Chen, Shu-Han,Ou, Tian-Miao,Tan, Jia-Heng,Li, Ding,Gu, Lian-Quan,Huang, Zhi-Shu. "Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase". scheme or table. p. 2074 - 2083. Retrieved 2011/05/05.