S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

Base Information

Chemical Name:S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate
CAS No.:940943-37-3
Molecular Formula:C₂₀H₂₅N₃O₅S₂
Molecular Weight:451.568
Hs Code.:
UNII:26UQK478QL
ChEMBL ID:CHEMBL488583
Wikidata:Q27254131
Mol file:940943-37-3.mol

Synonyms:KD 5170;KD-5170;KD5170

Suppliers and Price of S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
KD 5170
10mg
$ 466.00

Crysdot
S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl)ethanethioate 95+%
250mg
$ 388.00

Crysdot
S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl)ethanethioate 95+%
1g
$ 970.00

Chemenu
S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl)ethanethioate 95%
1g
$ 916.00

Cayman Chemical
KD 5170 ≥98%
25mg
$ 339.00

Cayman Chemical
KD 5170 ≥98%
5mg
$ 102.00

Cayman Chemical
KD 5170 ≥98%
1mg
$ 28.00

Cayman Chemical
KD 5170 ≥98%
10mg
$ 150.00

ApexBio Technology
KD5170
10mg
$ 182.00

ApexBio Technology
KD5170
10mM (in 1mL DMSO)
$ 170.00

Total 9 raw suppliers

Chemical Property of S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

Chemical Property:

Storage Temp.:Sealed in dry,Room Temperature
Solubility.:≥21.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:12
Exact Mass:451.12356325
Heavy Atom Count:30
Complexity:658

Purity/Quality:

97% ^*data from raw suppliers

KD 5170 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C
Description KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity in vitro and in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.

Technology Process of S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

There total 2 articles about S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 940943-40-8
N-(5-Acetyl-pyridin-2-yl)-4-(3-dimethylamino-propoxy)-benzenesulfonamide

: 10387-40-3
potassium thioacetate

: 940943-37-3
KD₅₁₇₀

Guidance literature:: N-(5-Acetyl-pyridin-2-yl)-4-(3-dimethylamino-propoxy)-benzenesulfonamide; With hydrogen bromide; In acetic acid; N,N-dimethyl-formamide; at 45 ℃;

With pyrrolidone hydrotribromide; In acetic acid; N,N-dimethyl-formamide; at 50 ℃; for 1h;

potassium thioacetate; With dipotassium hydrogenphosphate; more than 3 stages;

Reference yield:

: C₁₈H₂₂BrN₃O₄S

: 10387-40-3
potassium thioacetate

: 940943-37-3
KD₅₁₇₀

Guidance literature:: C₁₈H₂₂BrN₃O₄S; potassium thioacetate; In acetic acid; N,N-dimethyl-formamide; at 20 - 35 ℃; for 1h;

With dipotassium hydrogenphosphate; In dichloromethane; water; for 0.25h;