2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester

Base Information

• Chemical Name: 2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester
• CAS No.: 1185836-97-8
• Molecular Formula: C16H24BFO4
• Molecular Weight: 292.158
• Hs Code.: 2931900090
• Mol file: 1185836-97-8.mol

Synonyms:2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester;2-(2-Cyclopropylmethoxy-5-fluorophenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Chemical Property of 2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester

Chemical Property:

• PSA: 27.69000
• LogP: 2.91370

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Cyclopropylmethoxy-5-fluorophenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester

There total 1 articles about 2-CyclopropylMethoxy-5-fluorophenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1185836-97-8)

Guidance literature:

Reference yield: 34.0%

2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1185836-97-8) + ethyl 1-bromo-3-methyl-4-oxo-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyridine-6-carboxylate → ethyl 1-(2-(cyclopropylmethoxy)-5-fluorophenyl)-3-methyl-4-oxo-2-((2-(trimethylsilyl)ethoxy)methyl)-4,5-dihydro-2H-pyrrolo[3,4-c]pyridine-6-carboxylate

Guidance literature:

With potassium phosphate; (2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II)chloride; In tetrahydrofuran; water; at 20 - 40 ℃; Inert atmosphere;

Reference yield:

2-(2-(cyclopropylmethoxy)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1185836-97-8) → 1-(2-(cyclopropylmethoxy)-5-fluorophenyl)-3-methyl-6-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrrolo[3,4-c]pyridin-4(5H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: (2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II)chloride; potassium phosphate / tetrahydrofuran; water / 20 - 40 °C / Inert atmosphere

2: caesium carbonate / toluene / 1 h / 180 °C / Microwave irradiation

With potassium phosphate; (2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II)chloride; caesium carbonate; In tetrahydrofuran; water; toluene;