1-(4-Benzylpiperazin-1-yl)propan-2-amine

Base Information

Chemical Name:1-(4-Benzylpiperazin-1-yl)propan-2-amine
CAS No.:133025-64-6
Molecular Formula:C₁₄H₂₃N₃
Molecular Weight:233.357
Hs Code.:
DSSTox Substance ID:DTXSID20564210
Mol file:133025-64-6.mol

Synonyms:1-(4-benzylpiperazin-1-yl)propan-2-amine;133025-64-6;starbld0014849;SCHEMBL8446786;DTXSID20564210;AKOS000161864;AKOS022420192

Suppliers and Price of 1-(4-Benzylpiperazin-1-yl)propan-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ALPHA-METHYL-4-(PHENYLMETHYL)-1-PIPERAZINEETHANAMINE 95.00%
5MG
$ 505.46

Total 2 raw suppliers

Chemical Property of 1-(4-Benzylpiperazin-1-yl)propan-2-amine

Chemical Property:

Boiling Point:345.1±27.0 °C(Predicted)
PKA:10.15±0.10(Predicted)
PSA：32.50000
Density:1.037±0.06 g/cm3(Predicted)
LogP:1.72750
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:233.189197746
Heavy Atom Count:17
Complexity:206

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

ALPHA-METHYL-4-(PHENYLMETHYL)-1-PIPERAZINEETHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CN1CCN(CC1)CC2=CC=CC=C2)N

Technology Process of 1-(4-Benzylpiperazin-1-yl)propan-2-amine

There total 9 articles about 1-(4-Benzylpiperazin-1-yl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1236265-35-2
(R)-alanine-N-(4-benzyl-1-piperazinyl)carboxamide dihydrochloride

: 256352-18-8,133025-64-6
(R)-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]amine

Guidance literature:: With borane; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm9806704

Reference yield:

: 1236265-35-2
(S)-alanine-N-(4-benzyl-1-piperazinyl)carboxamide dihydrochloride

: 133025-64-6
(S)-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]amine

Guidance literature:: With borane; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jm9806704

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 133025-64-6
(S)-[1-methyl-2-(4-benzyl-1-piperazinyl)ethyl]amine

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl cyanophosphonate; Et₃N / CH₂Cl₂

2: 4.6 N HCl / ethyl acetate / 1 h / 20 °C

3: BH₃ / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; diethyl cyanophosphonate; borane; triethylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; 1: Condensation / 2: deprotection / 3: Reduction;
DOI:10.1021/jm9806704