1-(6-Methoxy-2-naphthyl)ethanamine

Base Information

• Chemical Name: 1-(6-Methoxy-2-naphthyl)ethanamine
• CAS No.: 133097-30-0
• Molecular Formula: C13H15NO
• Molecular Weight: 201.268
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID70442074
• Nikkaji Number: J3.410.952D
• Mol file: 133097-30-0.mol

Synonyms:133097-30-0;1-(6-methoxynaphthalen-2-yl)ethanamine;1-(6-methoxy-2-naphthyl)ethanamine;2-Naphthalenemethanamine, 6-methoxy-alpha-methyl-;2-Naphthalenemethanamine, 6-methoxy-alpha-methyl-, (alphaR)-;SCHEMBL1746118;DTXSID70442074;AKOS000185750;AKOS022184968;SB77684;1-(6-Methoxy-2-naphthyl)ethanamine x1hcl;Y13743;alpha-Methyl-6-methoxynaphthalene-2-methaneamine;1-(6-METHOXYNAPHTHALEN-2-YL)ETHAN-1-AMINE

Chemical Property of 1-(6-Methoxy-2-naphthyl)ethanamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 341.407°C at 760 mmHg
• PKA: 9?+-.0.29(Predicted)
• Flash Point: 165.412°C
• PSA: 35.25000
• Density: 1.089g/cm³
• LogP: 3.56840
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 201.115364102
• Heavy Atom Count: 15
• Complexity: 207

Purity/Quality:

98% ^*data from raw suppliers

[1-(6-Methoxy-2-naphthyl)ethyl]amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC2=C(C=C1)C=C(C=C2)OC)N

Technology Process of 1-(6-Methoxy-2-naphthyl)ethanamine

There total 5 articles about 1-(6-Methoxy-2-naphthyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

6-methoxy-2-acetylnaphthalene (3900-45-6) → <1-(6-Methoxy-2-naphthyl)ethyl>amin (133097-30-0)

Guidance literature:

With 4-methoxy-N-(1-(naphthalen-2-yl)ethylidene)aniline; ammonium formate; In methanol; at 80 ℃; for 12h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201303541

Reference yield: 94.0%

benzyl (1-(6-methoxynaphthalen-2-yl)ethyl)carbamate → <1-(6-Methoxy-2-naphthyl)ethyl>amin (133097-30-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 1h;

DOI:10.1039/c6ob01178k

Reference yield: 94.0%

→ <1-(6-Methoxy-2-naphthyl)ethyl>amin (133097-30-0)

Guidance literature:

With ammonium formate; In methanol; at 80 ℃; for 0.166667h; Inert atmosphere;

With formic acid; C₂₉H₃₂ClIrNO; triethylamine; In methanol; at 80 ℃;

upstream raw materials:

6-methoxy-2-acetylnaphthalene

1-(6-methoxynaphthalen-2-yl)ethanone oxime

Downstream raw materials:

6-methoxy-2-acetylnaphthalene

(S)-<1-(6-Methoxy-2-naphthyl)ethyl>amin

(R)-<1-(6-Methoxy-2-naphthyl)ethyl>amin

Refernces

• 1、 -. "COMPOUND HAVING MUTANT IDH INHIBITORY ACTIVITY, PREPARATION METHOD AND USE THEREOF". . . Retrieved 2019/02/09.
• 2、 -. "CATALYST COMPOUNDS". Paragraph 0314; 0321. . Retrieved 2015/03/28.