Ramipril Benzyl Ester

Base Information Edit

Chemical Name:Ramipril Benzyl Ester
CAS No.:87269-88-3
Molecular Formula:C30H38N2O5
Molecular Weight:506.642
Hs Code.:
DSSTox Substance ID:DTXSID00435838
Nikkaji Number:J2.155.416B
Wikidata:Q82250952
Mol file:87269-88-3.mol

Synonyms:benzyl (2S,3aS,6aS)-1-((2S)-2-(((1S)-1-ethoxycarbonyl-3-phenyl-propyl)amino)propanoyl)-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta(b)pyrrole-2-carboxylate;ramipril benzyl ester

Suppliers and Price of Ramipril Benzyl Ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RamiprilBenzylEster
10mg
$ 1100.00

Medical Isotopes, Inc.
RamiprilBenzylEster
1 mg
$ 625.00

Total 1 raw suppliers

Chemical Property of Ramipril Benzyl Ester Edit

Chemical Property:

Boiling Point:652.6±55.0 °C(Predicted)
PKA:5.44±0.39(Predicted)
PSA：84.94000
Density:1.170±0.06 g/cm3(Predicted)
LogP:4.37080
Solubility.:Chloroform, Dichloromethane
XLogP3:5.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:13
Exact Mass:506.27807232
Heavy Atom Count:37
Complexity:761

Purity/Quality:

98% ^*data from raw suppliers

RamiprilBenzylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(=O)OCC4=CC=CC=C4
Isomeric SMILES:CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)OCC4=CC=CC=C4
Uses Ramipril Benzyl Ester is a substituted Ramipril (R111000), as active angiotensin converting enzyme (ACE) inhibitor.

Technology Process of Ramipril Benzyl Ester

There total 26 articles about Ramipril Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

: (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

: 82717-96-2,122076-80-6
[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine

: 87269-88-3,1356847-95-4,1356352-52-7
2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

Guidance literature:: [1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanine; With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at -10 - -5 ℃; for 0.00416667h; Inert atmosphere;

(2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride; With sodium hydrogencarbonate; In dichloromethane; water; for 0.005h;

Reference yield: 99.0%

: (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride

: 84793-24-8
N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride

: 87269-88-3,1356847-95-4,1356352-52-7
2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

Guidance literature:: (2S,3aS,6aS)-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester hydrochloride; With sodium hydrogencarbonate; In water; ethyl acetate; at 15 ℃; for 0.0833333h;

N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride; In water; ethyl acetate; at 20 ℃; for 1.08333h;