3-Methoxy-4-(trifluoromethoxy)benzaldehyde

Base Information

Chemical Name:3-Methoxy-4-(trifluoromethoxy)benzaldehyde
CAS No.:1261483-00-4
Molecular Formula:C9H7F3O3
Molecular Weight:220.148
Hs Code.:
European Community (EC) Number:889-040-5
Mol file:1261483-00-4.mol

Synonyms:3-methoxy-4-(trifluoromethoxy)benzaldehyde;1261483-00-4;SCHEMBL18239636;XAHZURBOVLDNLP-UHFFFAOYSA-N;MFCD18398417;CS-0193925;E91541

Suppliers and Price of 3-Methoxy-4-(trifluoromethoxy)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-Methoxy-4-(trifluoromethoxy)benzaldehyde 97%
1g
$ 1270.00

AOBChem
3-Methoxy-4-(trifluoromethoxy)benzaldehyde 95%
1g
$ 553.00

AOBChem
3-Methoxy-4-(trifluoromethoxy)benzaldehyde 95%
5g
$ 1976.00

Alichem
3-Methoxy-4-(trifluoromethoxy)benzaldehyde
1g
$ 1549.60

Total 6 raw suppliers

Chemical Property of 3-Methoxy-4-(trifluoromethoxy)benzaldehyde

Chemical Property:

PSA：35.53000
LogP:2.40630
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:220.03472857
Heavy Atom Count:15
Complexity:217

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

3-Methoxy-4-(trifluoromethoxy)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=CC(=C1)C=O)OC(F)(F)F

Technology Process of 3-Methoxy-4-(trifluoromethoxy)benzaldehyde

There total 5 articles about 3-Methoxy-4-(trifluoromethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1261750-52-0
3-methoxy-4-(trifluoromethoxy)-benzyl alcohol

: 1261483-00-4
3-methoxy-4-(trifluoromethoxy)benzaldehyde

Guidance literature:: With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm1010644

Reference yield:

: 1321963-21-6
tert-butyldimethyl-(4-(trifluoromethoxy)benzyloxy)silane

: 1261483-00-4
3-methoxy-4-(trifluoromethoxy)benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 0.5 h / -78 - 20 °C

1.3: 0.33 h

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

With N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; sec.-butyllithium; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm1010644

Reference yield:

: 1321963-25-0
5-((tert-butyldimethylsilyloxy)methyl)-2-(trifluoromethoxy)-phenol

: 1261483-00-4
3-methoxy-4-(trifluoromethoxy)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C

With tetrabutyl ammonium fluoride; potassium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1010644