Chroman-5-carboxylic acid

Base Information

• Chemical Name: Chroman-5-carboxylic acid
• CAS No.: 209256-64-4
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• European Community (EC) Number: 966-206-6
• Mol file: 209256-64-4.mol

Synonyms:chroman-5-carboxylic acid;209256-64-4;Chromane-5-carboxylic acid;3,4-dihydro-2H-chromene-5-carboxylic acid;2H-1-Benzopyran-5-carboxylic acid, 3,4-dihydro-;3,4-DIHYDRO-2H-1-BENZOPYRAN-5-CARBOXYLIC ACID;chroman-5-carboxylicacid;SCHEMBL984633;GOHXEALVTBUNGX-UHFFFAOYSA-N;MFCD18157618;SB35272;DB-351154;CS-0107187;EN300-1722798;A924417

Chemical Property of Chroman-5-carboxylic acid

Chemical Property:

• PSA: 46.53000
• LogP: 1.70980
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 178.062994177
• Heavy Atom Count: 13
• Complexity: 202

Purity/Quality:

98.5% ^*data from raw suppliers

chroman-5-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C=CC=C2OC1)C(=O)O

Technology Process of Chroman-5-carboxylic acid

There total 5 articles about Chroman-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2H-chromene-5-carboxylic acid (843652-50-6) → chroman-5-carboxylic acid (209256-64-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 750.075 Torr;

Reference yield:

5-Carboethoxychroman (53596-63-7) → chroman-5-carboxylic acid (209256-64-4)

Guidance literature:

5-Carboethoxychroman; With sodium hydroxide; In water; for 2h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

methyl chromane-5-carboxylate (1202863-90-8) → chroman-5-carboxylic acid (209256-64-4)

Guidance literature:

With water; sodium hydroxide;

upstream raw materials:

5-Carboethoxychroman

2H-chromene-5-carboxylic acid

methyl chromane-5-carboxylate

2-allyl-3-hydroxybenzoic acid ethyl ester

Refernces

• 1、 -. "AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS". Page/Page column 33. . Retrieved 2010/09/07.
• 2、 -. "2-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES". Page/Page column 75. . Retrieved 2008/12/07.