trans-4-Amino-1-boc-3-hydroxypiperidine

Base Information

• Chemical Name: trans-4-Amino-1-boc-3-hydroxypiperidine
• CAS No.: 443955-98-4
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.2774
• Hs Code.: 2933399090
• European Community (EC) Number: 850-589-0,882-763-7
• DSSTox Substance ID: DTXSID70444033
• Wikidata: Q82262036
• Mol file: 443955-98-4.mol

Synonyms:443955-98-4;1007596-95-3;TRANS-4-AMINO-1-BOC-3-HYDROXYPIPERIDINE;tert-butyl (3R,4R)-4-amino-3-hydroxypiperidine-1-carboxylate;(3R,4R)-tert-Butyl 4-amino-3-hydroxypiperidine-1-carboxylate;(3r,4r)-rel-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate;t-Butyl (3R,4R)-4-amino-3-hydroxypiperidine-1-carboxylate;(3R,4R)-4-Amino-1-boc-3-hydroxypiperidine;trans-1-Boc-4-amino-3-hydroxy-piperidine;Tert-butyl (3R,4R)-4-amino-3-hydroxy-piperidine-1-carboxylate;(3R,4R)-1-Boc-4-amino-3-hydroxy-piperidine;tert-butyl trans-4-amino-3-hydroxypiperidine-1-carboxylate;SCHEMBL1219597;DTXSID70444033;KREUZCYJWPQPJX-HTQZYQBOSA-N;AMY16968;MFCD18072074;MFCD18425632;TRANS-TERT-BUTYL 4-AMINO-3-HYDROXYPIPERIDINE-1-CARBOXYLATE;AKOS022185573;DS-7572;trans-1-BOC-4-Amino-3-hydroxypiperidine;trans (1-Boc)-4-amino-3-hydroxypiperidine;CS-0058588;(3R,4R)-(1-Boc)-4-Amino-3-hydroxypiperidine;EN300-1177745;EN300-7022909;A872538;A902546;(3R,4R)-tert-Butyl4-amino-3-hydroxypiperidine-1-carboxylate;tert-butyl (3R,4R)-4-amino-3-hydroxy-1-piperidinecarboxylate;trans(+/-)tert-Butyl-4-amino-3-hydroxypiperidine-1-carboxylate;rac-tert-butyl (3R,4R)-4-amino-3-hydroxypiperidine-1-carboxylate;tert-Butyl (3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate;tert-butyl trans(+/-)-4-amino-3-hydroxypiperidine-1-carboxylate;tert-Butyl(3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylate;(+/-) trans-1,1-dimethylethyl 4-amino-3-hydroxy-1-piperidinecarboxylate;(3R*,4R*)-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;(3R,4R)-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;Rac trans-4-Amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;rac-trans-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;TERT-BUTYL (3R*,4R*)-4-AMINO-3-HYDROXY-1-PIPERIDINECARBOXYLATE;trans-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;(+/-)-trans-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-amino-3-hydroxy-, 1,1-dimethylethyl ester, (3R,4R)-;racemic trans-4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of trans-4-Amino-1-boc-3-hydroxypiperidine

Chemical Property:

• Boiling Point: 326.1±42.0 °C(Predicted)
• PKA: 14.37±0.40(Predicted)
• PSA: 75.79000
• Density: 1.142±0.06 g/cm3(Predicted)
• LogP: 0.95360
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 216.14739250
• Heavy Atom Count: 15
• Complexity: 237

Purity/Quality:

95-99% ^*data from raw suppliers

trans-4-Amino-1-Boc-3-hydroxypiperidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(C(C1)O)N
• Isomeric SMILES: CC(C)(C)OC(=O)N1CC[C@H]([C@@H](C1)O)N

Technology Process of trans-4-Amino-1-boc-3-hydroxypiperidine

There total 32 articles about trans-4-Amino-1-boc-3-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R*,4R*)-tert-butyl 3-azido-4-hydroxypiperidine-1-carboxylate → rac-(3S,4S)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (1331777-74-2,443955-98-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 99.0%

trans-tert-butyl-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate → rac-(3S,4S)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate (1331777-74-2,443955-98-4)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In ethanol; for 6h; under 2068.65 Torr;

Reference yield: 94.0%

tert-butyl (3RS,4RS)-4-azido-3-hydroxy-piperidine-1-carboxylate (203503-02-0) → 4-amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (203503-03-1,1331777-74-2,443955-98-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate

di-tert-butyl dicarbonate

1,2,3,6-tetrahydropyridine

N-Boc-1,2,3,6-tetrahydropyridine

Downstream raw materials:

(3R,4R)-tert-butyl 3-azido-4-[(diphenylmethylene)amino]piperidine-1-carboxylate

Refernces

• 1、 -. "PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYR-ROLO[2,3-D]PYRIDINYL ACRYLAMIDES". . . Retrieved 2015/06/17.
• 2、 Lv, Kai,Wu, Jinwei,Wang, Jian,Liu, Mingliang,Wei, Zengquan,Cao, Jue,Sun, Yexin,Guo, Huiyuan. "Synthesis and in vitro antibacterial activity of quinolone/naphthyridone derivatives containing 3-alkoxyimino-4-(methyl)aminopiperidine scaffolds". . p. 1754 - 1759. Retrieved 2013/04/10.