6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde

Base Information

• Chemical Name: 6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde
• CAS No.: 887979-25-1
• Molecular Formula: C₁₃H₈F₃NO₂
• Molecular Weight: 267.207
• Hs Code.: 2933399990
• Mol file: 887979-25-1.mol

Synonyms:6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde;6-[4-(trifluoromethoxy)phenyl]-2-Pyridinecarboxaldehyde

Chemical Property of 6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde

Chemical Property:

• PSA: 39.19000
• LogP: 3.45970

Purity/Quality:

99% ^*data from raw suppliers

6-[4-(Trifluoromethoxy)phenyl]-2-pyridinecarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde

There total 1 articles about 6-[4-(TrifluoroMethoxy)phenyl]-2-pyridinecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + 4-trifluoromethoxyphenylboronic acid (139301-27-2) → 6-(4-(trifluoromethoxy)phenyl)picolinaldehyde (887979-25-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; Inert atmosphere; Reflux;

DOI:10.1039/c5md00062a

Reference yield:

6-(4-(trifluoromethoxy)phenyl)picolinaldehyde (887979-25-1) → C15H12F3NO2

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 1: |Grignard Reaction;

DOI:10.1039/c5md00062a

Reference yield:

6-(4-(trifluoromethoxy)phenyl)picolinaldehyde (887979-25-1) → 7-methoxy-3-methyl-2-(6-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)quinolin-4(1H)-one

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: trifluorormethanesulfonic acid / butan-1-ol / 24 h / Reflux

With trifluorormethanesulfonic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; butan-1-ol; 1: |Grignard Reaction;

DOI:10.1039/c5md00062a

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

4-trifluoromethoxyphenylboronic acid

Refernces