Chemical Property of (2S,3S)-2-Amino-3-methyl-N-(2-morpholinoethyl)pentanamide
Chemical Property:
- PSA：71.08000
- LogP:1.28670
- Storage Temp.:-20°C
- Solubility.:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 30 mg/ml)
- XLogP3:0
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:6
- Exact Mass:243.19467705
- Heavy Atom Count:17
- Complexity:230
- Purity/Quality:
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97% *data from raw suppliers
(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamideHydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CCC(C)C(C(=O)NCCN1CCOCC1)N
- Isomeric SMILES:CC[C@H](C)[C@@H](C(=O)NCCN1CCOCC1)N
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Description
LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand that inhibits nerve growth factor (NGF) binding to p75NTR-Fc (A2 = 1,192 nM). It inhibits DNA damage in and promotes survival of hippocampal neuronal cultures in a p75NTR- and concentration-dependent manner. LMA11A-31 also inhibits proNGF-induced cell death of mature oligodendrocytes. In vivo, LMA11A-31 (10-100 mg/kg) improves motor function and coordination in the weight-bearing open-field test and nonweight-bearing swim test and increases survival of oligodendrocytes in a mouse model of spinal contusion injury. It prevents and/or reverses atrophy of forebrain cholinergic neurites and cortical dystrophic neurites in Thy-1 hAPPLond/Swe and Tg2576 mice with mid- to late stage Alzheimer''s disease. It also reduces excessive alcohol self-administration in rats and decreases huntingtin (Htt) aggregate formation and striatal cholinergic degeneration in the R6/2 mouse model of Huntington''s disease.
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Uses
(2S,3S)-2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]pentanamide is used for the preparation of peptideamides for treatment of retroviral infection.
