Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI)

Base Information

• Chemical Name: Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI)
• CAS No.: 693826-78-7
• Molecular Formula: C9H11F3O
• Molecular Weight: 192.1782496
• Mol file: 693826-78-7.mol

Synonyms:Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI)

Chemical Property of Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 2.12340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI)

There total 4 articles about Bicyclo[2.2.1]hept-5-ene-2-methanol, 2-(trifluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester (597581-42-5) → 2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-methanol (693826-78-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 5h;

DOI:10.1021/jo060893z

Reference yield:

2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-carboxylic acid (370102-78-6) → 2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-methanol (693826-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / acetone / 5 h / Heating

2: 82 percent / LiAlH₄ / diethyl ether / 5 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; acetone;

DOI:10.1021/jo060893z

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → 2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-methanol (693826-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / CH₂Cl₂ / 12 h / 20 °C

2: 99 percent / K₂CO₃ / acetone / 5 h / Heating

3: 82 percent / LiAlH₄ / diethyl ether / 5 h / 20 °C

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; dichloromethane; acetone; 1: Diels-Alder reaction;

DOI:10.1021/jo060893z

upstream raw materials:

2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester

cyclopenta-1,3-diene

2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Downstream raw materials:

toluene-4-sulfonic acid 2-trifluoromethylbicyclo[2.2.1]hept-5-ene-2-methyl ester