(2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide

Base Information

Chemical Name:(2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide
CAS No.:137302-63-7
Molecular Formula:C36H54F2N6O9S
Molecular Weight:0
Hs Code.:
Mol file:137302-63-7.mol

(2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide

Synonyms:(2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide;(4S)-4-[(S)-2-(N-Morpholinosulfonyl-O-methyl-L-Tyr-amino)-4-pentenoylamino]-5-cyclohexyl-2,2-difluoro-3-oxo-N-(2-morpholinoethyl)pentanamide

Suppliers and Price of (2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide

Chemical Property:

PSA：193.09000
LogP:3.46200

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide

There total 9 articles about (2S)-N-[(1S)-1-(Cyclohexylmethyl)-3,3-difluoro-4-[(2-morpholinoethyl)amino]-2,4-dioxobutyl]-2-[[O-methyl-N-(morpholinosulfonyl)-L-tyrosyl]amino]-4-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 137302-60-4
O-methyl-N-(4-morpholinylsulfonyl)-L-tyrosyl-N-<1-(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-4,5-didehydro-L-norvalinamide

: 137302-63-7
O-methyl-N-(4-morpholinylsulfonyl)-L-tyrosyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: With dichloro-acetic acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide; In dichloromethane; dimethyl sulfoxide; 1.) 0 deg C, 2.) RT, 18 h;
DOI:10.1021/jm00079a001

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 137302-63-7
O-methyl-N-(4-morpholinylsulfonyl)-L-tyrosyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

3: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

4: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

5: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

6: 84 percent / dichloroacetic acid, DCC, DMSO / dimethylsulfoxide; CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 18 h

With hydrogenchloride; dichloro-acetic acid; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 137302-63-7
O-methyl-N-(4-morpholinylsulfonyl)-L-tyrosyl-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-4,5-didehydro-L-norvalinamide

Guidance literature:: Multi-step reaction with 8 steps

1: Zn, I₂ / tetrahydrofuran / 0.5 h / Heating

2: 79 percent / NaOH / tetrahydrofuran / 4 h

3: 56 percent / HOBT, DCC / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

4: 93 percent / HCl gas / CHCl₃; methanol / 1 h / Ambient temperature

5: 80 percent / HOBT, DCC / CH₂Cl₂ / 1.) 0 deg C, 2 h, 2.) RT, 16 h

6: 3.50 g / HCl gas / CH₂Cl₂; methanol / 0.25 h / Ambient temperature

7: HOBT, DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

8: 84 percent / dichloroacetic acid, DCC, DMSO / dimethylsulfoxide; CH₂Cl₂ / 1.) 0 deg C, 2.) RT, 18 h

With hydrogenchloride; dichloro-acetic acid; sodium hydroxide; iodine; benzotriazol-1-ol; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a001