3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE

Base Information

• Chemical Name: 3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE
• CAS No.: 57329-34-7
• Molecular Formula: C11H10O2
• Molecular Weight: 174.2
• Mol file: 57329-34-7.mol

Synonyms:3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE;ASINEX-REAG BAS 10154033;2-Benzofurancarboxaldehyde, 5-fluoro-3-Methyl-;5-fluoro-3-methylbenzofuran-2-carbaldehyde

Chemical Property of 3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE

Chemical Property:

• PSA: 30.21000
• LogP: 2.69280

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-fluoro-3-methylbenzofuran-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE

There total 3 articles about 3,5-DIMETHYL-BENZOFURAN-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

ethyl 5-fluoro-3-methylbenzofuran-2-carboxylate → 5-fluoro-3-methylbenzofuran-2-carbaldehyde (57329-34-7)

Guidance literature:

ethyl 5-fluoro-3-methylbenzofuran-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

With Dess-Martin periodane; In dichloromethane;

DOI:10.1039/c6ob02569b

Reference yield:

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one (394-32-1) → 5-fluoro-3-methylbenzofuran-2-carbaldehyde (57329-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile; N,N-dimethyl-formamide / 72 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c6ob02569b

Reference yield:

→ 5-fluoro-3-methylbenzofuran-2-carbaldehyde (57329-34-7)

Guidance literature:

5-Fluor-3-methylbenzofuran, Dimethylformamid/POCl3;

upstream raw materials:

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

Refernces