(6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol

Base Information

Chemical Name:(6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol
CAS No.:22663-41-8
Molecular Formula:C23H34O2
Molecular Weight:342.51486
Hs Code.:
Mol file:22663-41-8.mol

Synonyms:(-)-1',1'-Dimethyl-Δ8-tetrahydrocannabinol;(6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol

Chemical Property:

PSA：29.46000
LogP:6.47090

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol

There total 6 articles about (6aR)-3-(1,1-Dimethylpentyl)-6aβ,7,10,10aα-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 22930-09-2
2-(3,5-dihydroxyphenyl)-2-methylhexane

: 861892-40-2
(4R)-1-methyl-4-(2-(1-propylene))-2-cyclohexene-2-ol

: 22663-41-8
(6aR,10aR)-6,6,9-trimethyl-3-(2-methylhexan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 20 - 80 ℃; for 7h; Dean-Stark;

Reference yield: 78.0%

: 22972-51-6
(1S,4R)-p-mentha-2,8-dien-1-ol

: 22930-09-2
2-(3,5-dihydroxyphenyl)-2-methylhexane

: 22663-41-8
(6aR,10aR)-6,6,9-trimethyl-3-(2-methylhexan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.1016/S0968-0896(02)00649-1

Reference yield:

: 22972-63-0
α,α-dimethyl-3,5-dimethoxyphenylacetonitrile

: 22663-41-8
(6aR,10aR)-6,6,9-trimethyl-3-(2-methylhexan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

2.2: 48 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 18 h / 20 °C / 760.05 Torr

4.1: boron tribromide / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / toluene / 7 h / 20 - 80 °C / Dean-Stark

With palladium 10% on activated carbon; hydrogen; boron tribromide; diisobutylaluminium hydride; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethyl acetate; toluene;