3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID

Base Information

• Chemical Name: 3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID
• CAS No.: 799283-53-7
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.401
• Hs Code.: 2933399090
• Mol file: 799283-53-7.mol

Synonyms:3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID;1-Boc-4-[(3-carboxyphenyl)methyl]piperidine

Chemical Property of 3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID

Chemical Property:

• PSA: 66.84000
• LogP: 3.51230
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(3-Carboxybenzyl)-piperidine-1-carboxylic acid tert-butyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID

There total 1 articles about 3-BOC-4-[(PIPERIDINYL)METHYL]BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H29NO4 (799283-52-6) → 3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]benzoic acid (799283-53-7)

Guidance literature:

C₂₀H₂₉NO₄; With sodium hydroxide; water; In methanol; at 50 ℃; for 2h;

With hydrogenchloride; In methanol; water; at 0 ℃;

Reference yield: 94.2%

3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]benzoic acid (799283-53-7) + 3-bromo-4-fluoro-benzylamine (388072-39-7) → 1,1-dimethylethyl 4-{[3-({[(3-bromo-4-fluorophenyl)methyl]amino}carbonyl)phenyl]methyl}-1-piperidinecarboxylate (887920-69-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 80.0%

3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]benzoic acid (799283-53-7) + phenylmethyl (2S)-4-{[5'-(aminomethyl)-2'-fluoro-3-biphenylyl]methyl}-2-methyl-1-piperazinecarboxylate (887917-54-6) → phenylmethyl (2S)-4-[(5'-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate (887917-55-7)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

C₂₀H₂₉NO₄

Downstream raw materials:

1,1-dimethylethyl 4-{[3-({[(3-bromo-4-fluorophenyl)methyl]amino}carbonyl)phenyl]methyl}-1-piperidinecarboxylate

1,1-dimethylethyl (2S)-4-[(5'-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate

phenylmethyl (2S)-4-[(5'-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2'-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate

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