Nintedanib

Base Information

Chemical Name:Nintedanib
CAS No.:1174335-83-1
Molecular Formula:C20H16ClNO5
Molecular Weight:385.804
Hs Code.:
Mol file:1174335-83-1.mol

Synonyms:methyl-1 -(chloroacetyl)-3- [methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylate;1H-Indole-6-carboxylic acid, 1-(2-chloroacetyl)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-;(3E)-1-(2-Chloroacetyl)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylic acid methyl ester;methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate;1-(2-chloroacetyl)-3-[1-methoxy-1-phenylmeth-(E)-ylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester;Nintedanib Impurity 2 (Intedanib Impurity 2);(E)-methyl 1-(2-chloroacetyl)-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Suppliers and Price of Nintedanib

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
1H-Indole-6-carboxylicacid,1-(2-chloroacetyl)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-,methylester,(3E)-
100mg
$ 258.00

Total 19 raw suppliers

Chemical Property of Nintedanib

Chemical Property:

Boiling Point:571.9±50.0 °C(Predicted)
PKA:-2.57±0.20(Predicted)
PSA：72.91000
Density:1.374±0.06 g/cm3(Predicted)
LogP:3.16490

Purity/Quality:

99.9% ^*data from raw suppliers

1H-Indole-6-carboxylicacid,1-(2-chloroacetyl)-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-,methylester,(3E)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Nintedanib

There total 6 articles about Nintedanib which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1160293-25-3
methyl 1-(2-chloroacetyl)-2-oxoindoline-6-carboxylate

: 707-07-3
orthobenzoic acid trimethyl ester

: 1174335-83-1
(E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate

Guidance literature:: With acetic anhydride; In toluene; at 20 - 110 ℃; for 4h;

Reference yield:

: 1-cholroacetyl-2-indolone-6-methylformate

: 707-07-3
orthobenzoic acid trimethyl ester

: 1174335-83-1
(E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate

Guidance literature:: With acetic anhydride; In toluene; at 110 ℃; for 4h;

Reference yield:

: 14192-26-8
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 1174335-83-1
(E)-1-cholroacetyl-3-(methoxy(phenyl)methylene)-2-indolone-6-methylformate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 4 h / Reflux

2.1: acetic anhydride / toluene / Reflux

2.2: 120 h / 20 - 104 °C

With acetic anhydride; In toluene;