5-Fluoro ent-LaMivudine Acid D-Menthol Ester

Base Information

Chemical Name:5-Fluoro ent-LaMivudine Acid D-Menthol Ester
CAS No.:764659-79-2
Molecular Formula:C₁₈H₂₆FN₃O₄S
Molecular Weight:399.487
Hs Code.:2933599590
Mol file:764659-79-2.mol

Synonyms:5-Fluoro ent-LaMivudine Acid D-Menthol Ester;(2S,5R)-(1S,2R,5S)-2-Isopropyl-5-Methylcyclohexyl 5-(4-aMino-5-fluoro-2-oxopyriMidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate;(5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate;Emtricitabine Impurity V

Suppliers and Price of 5-Fluoro ent-LaMivudine Acid D-Menthol Ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
5-Fluoro ent-Lamivudine Acid D-Menthol Ester
5mg
$ 460.00

TRC
5-Fluoroent-LamivudineAcidD-MentholEster
5mg
$ 150.00

Medical Isotopes, Inc.
5-Fluoroent-LamivudineAcidD-MentholEster
50 mg
$ 2200.00

Medical Isotopes, Inc.
5-Fluoroent-LamivudineAcidD-MentholEster
5 mg
$ 650.00

Crysdot
(2S,5R)-(1S,2R,5S)-2-Isopropyl-5-methylcyclohexyl5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate 95+%
250mg
$ 2250.00

AvaChem
5-Fluoro ent-Lamivudine Acid D-Menthol Ester
25mg
$ 575.00

AvaChem
5-Fluoro ent-Lamivudine Acid D-Menthol Ester
10mg
$ 275.00

AvaChem
5-Fluoro ent-Lamivudine Acid D-Menthol Ester
5mg
$ 175.00

Total 9 raw suppliers

Chemical Property of 5-Fluoro ent-LaMivudine Acid D-Menthol Ester

Chemical Property:

Boiling Point:508.5±60.0 °C(Predicted)
PKA:2.40±0.10(Predicted)
PSA：121.74000
Density:1.47±0.1 g/cm3(Predicted)
LogP:3.13790
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro ent-Lamivudine Acid D-Menthol Ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Intermediate in the synthesis of ent-Emtricitabine (E525005).

Technology Process of 5-Fluoro ent-LaMivudine Acid D-Menthol Ester

There total 29 articles about 5-Fluoro ent-LaMivudine Acid D-Menthol Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

: C₂₁H₃₁FN₄O₄S

: 764659-72-5,764659-79-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: With hydrogenchloride; In dichloromethane; water; at 20 - 25 ℃;

Reference yield: 91.0%

: 2022-85-7
Flucytosine

: 147027-09-6,147126-67-8
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate

: 764659-72-5,764659-79-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-(methylcarbonyloxy)-1,3-oxathiolane-2-carboxylate; With triethylsilane; iodine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

Flucytosine; With N,O-bis-(trimethylsilyl)-acetamide; In dichloromethane; at 0 - 20 ℃; for 1h; Reagent/catalyst; stereoselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.5b00982

Reference yield: 81.0%

: 111878-21-8
2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine

: 288325-76-8
5S-chloro-[1,3]oxathiolane-2R-carboxilic acid 2-(1'R,2'S,5'R)-isopropyl-5-methyl-cyclohexyl ester

: 764659-72-5,764659-79-2
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxo-1,2-dihydro-1-pyrimidinyl)-1,3-oxathiolane-2-carboxylate

Guidance literature:: 2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine; 5S-chloro-[1,3]oxathiolane-2R-carboxilic acid 2-(1'R,2'S,5'R)-isopropyl-5-methyl-cyclohexyl ester; With triethylamine; In dichloromethane; at 42 - 45 ℃; for 19h; Heating / reflux;

With water; at 25 ℃; for 0.5h;