Miglustat hydrochloride

Base Information

Chemical Name:Miglustat hydrochloride
CAS No.:210110-90-0
Molecular Formula:C10H22ClNO4
Molecular Weight:255.742
Hs Code.:2933399990
European Community (EC) Number:874-729-5
ChEMBL ID:CHEMBL1329690
Mol file:210110-90-0.mol

Synonyms:210110-90-0;Miglustat hydrochloride;Miglustat (hydrochloride);N-Butyldeoxynojirimycin, Hydrochloride;N-Butyldeoxynojirimycin hydrochloride;SMR000058560;(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride;MLS000069516;Miglustat HCl;Opera_ID_475;N-Butyldeoxynojirimycin HCl;CHEMBL1329690;SCHEMBL11898780;NB-DNJ hydrochloride;OGT918 hydrochloride;N-Butyldeoxynojirimycin middot HCl;HY-17020A;MFCD00269940;AKOS024457437;N-Butyldeoxynojirimycin;AC-33704;AS-79087;N-(n-Butyl)deoxynojirimycin hydrochloride;N-Butyl-DNJ,HCl;Miglustat(hydrochloride);E73460;A912326;EN300-19750339;N-(N-BUTYL)DEOXYNOJIRIMYCIN, HYDROCHLORIDE;W-201839;(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-,3,4,5-Piperidinetriol Hydrochloride;(2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride;3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-, hydrochloride (1:1), (2R,3R,4R,5S)-

Suppliers and Price of Miglustat hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Butyldeoxynojirimycin, Hydrochloride
10mg
$ 418.00

Usbiological
N-Butyldeoxynojirimycin HCl
5mg
$ 389.00

TRC
N-Butyldeoxynojirimycin, Hydrochloride
50mg
$ 570.00

Tocris
Miglustathydrochloride
10
$ 227.00

Medical Isotopes, Inc.
N-ButyldeoxynojirimycinHCl
50 mg
$ 1960.00

DC Chemicals
Miglustat(hydrochloride) >98%
1 g
$ 3000.00

DC Chemicals
Miglustat(hydrochloride) >98%
250 mg
$ 1500.00

Crysdot
Miglustathydrochloride 98+%
5mg
$ 59.00

Crysdot
Miglustathydrochloride 98+%
10mg
$ 104.00

Cayman Chemical
N-Butyldeoxynojirimycin (hydrochloride) ≥98%
1mg
$ 32.00

Total 19 raw suppliers

Chemical Property of Miglustat hydrochloride

Chemical Property:

Vapor Pressure:7.37E-09mmHg at 25°C
Melting Point:169-172°C
Boiling Point:421.2°C at 760 mmHg
Flash Point:208.5°C
PSA：84.16000
LogP:-0.71440
Storage Temp.:Desiccate at -20°C
Solubility.:Soluble in DMSO (up to 20 mg/ml) or in Water (up to 20 mg/ml)
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:255.1237359
Heavy Atom Count:16
Complexity:190

Purity/Quality:

99%, ^*data from raw suppliers

N-Butyldeoxynojirimycin, Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCN1CC(C(C(C1CO)O)O)O.Cl
Isomeric SMILES:CCCCN1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O.Cl
Description Miglustat HCl (210110-90-0) is an orally active ceramide-specific glycosyltransferase and α-glucosidase I and II inhibitor.1 Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II.2 Pharmacological chaperone for glucocerebrosidase degradation.3 Clinically useful agent for Gaucher disease type 1.4 Stabilizes neurological disorders in Niemann-Pick disease type C.5
Uses An inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity. N-Butyldeoxynojirimycin has recently been used to retard lipid storage in the central nervous system of an animal m odel of Tay-Sachs disease. 1-Deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.

Technology Process of Miglustat hydrochloride

There total 1 articles about Miglustat hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%