KN-93 Phosphate

Base Information

• Chemical Name: KN-93 Phosphate
• CAS No.: 1188890-41-6
• Molecular Formula: C26 H29 Cl N2 O4 S . H3 O4 P
• Molecular Weight: 599.032641
• Mol file: 1188890-41-6.mol

Synonyms:Benzenesulfonamide, N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-, phosphate (1:1);N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4- methoxybenzenesulphonamide phosphate KN-93 Phosphate;KN-93 phosphate, >=98%;KN-93 phospate

Chemical Property of KN-93 Phosphate

Chemical Property:

• PSA: 166.03000
• LogP: 4.83360
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%+, ^*data from raw suppliers

KN 93 Phosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.
• Uses: KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.

Technology Process of KN-93 Phosphate

There total 1 articles about KN-93 Phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(2-{[[(2E)-3-(4-chlorophenyl)prop-2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide → N-(2-{[[(2E)-3-(4-chlorophenyl)prop-2-enyl](methyl)amino]methyl}phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate (1188890-41-6,1913269-12-1)

Guidance literature:

With phosphoric acid; In methanol; at 20 ℃;

DOI:10.1055/s-0030-1258298

Refernces